FABP4—a new therapeutic target for obesity and diabetes

Cayman Chemical is a leading provider of high-purity, active Fatty Acid Binding Proteins. Contact our sales staff for quotations on bulk preparations of FABP4 and FABP4 assay kits for your drug discovery efforts.

PIP Binding PH Domain Proteins

PtdIns phosphates (PIPs) initiate a cascade of responses, from cell growth and proliferation to survival and motility, that are involved in normal development but can also drive tumor progression. Cayman is introducing several highly specific PIP Binding Proteins with pleckstrin homology domains that bind PIP with high affinity and can be used to accurately detect specific PIPs in in vitro PI3-kinase and PTEN phosphatase assays.

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Statins

The “Statin” class of cholesterol-lowering agents function by inhibiting HMG CoA reductase, the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. Cayman carries a full line of HMG-CoA reductase inhibitors with varied potency for research applications.

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NO Donors

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. Cayman has just introduced 4 new RSNOs with half-lives ranging from 1 minute to more than 2 hours at pH 5.0.

Full information for NO Donors...