Cayman Chemical New Products

05-16 · 4-hydroxy DIPT (hydrochloride)

Wed, 16 May 2012 00:00:00 EDT

4-hydroxy DIPT is a short acting, synthetic tryptamine derivative with close structural similarity to the hallucinogen, psilocin, a natural compound found in Psilocybe, Panaeolus, and other psychoactive mushrooms. This product is intended for forensic and research applications.

05-16 · 4-hydroxy MET

Wed, 16 May 2012 00:00:00 EDT

4-hydroxy MET is a psychoactive synthetic tryptamine with structural and functional similarities to psilocin, a natural compound found in Psilocybe, Panaeolus, and other psychoactive mushrooms. This product is intended for forensic and research applications.

05-16 · Eprosartan (mesylate)

Wed, 16 May 2012 00:00:00 EDT

Angiotensin II, as part of the renin-angiotensin-aldosterone system, facilitates a sympathetic nervous system response mediated by the angiotensin II type 1 (AT1) receptor, causing vasoconstriction and subsequent increase in blood pressure. It potentiates noradrenaline release from sympathetic nerve terminals at the presynaptic level as well as amplifies the α-adrenoceptor-mediated vasoconstrictor response to endogenous noradrenaline. Angiotensin II receptor blockers (ARBs) are a major class of therapeutics designed to lower blood pressure and to provide cardiovascular protection.Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 – 3.9 nM and an elimination half-life of 5 to 7 hours. Eprosartan is structurally distinct from other noncompetitive ARBs in that it does not contain a biphenyl, tetrazole moiety and blocks angiotensin II receptors on both sympathetic nerve terminals and blood vessels.

05-16 · JWH 122 2-methylnaphthyl isomer

Wed, 16 May 2012 00:00:00 EDT

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both central CB1 (Ki = 0.69 nM) and peripheral CB2 (Ki = 1.2 nM) receptors. It has been detected in commercially-available herbal products. JWH 122 2-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 2, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

05-16 · JWH 122 3-methylnaphthyl isomer

Wed, 16 May 2012 00:00:00 EDT

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both central cannabinoid (CB1) (Ki = 0.69 nM) and peripheral cannabinoid (CB2) (Ki = 1.2 nM) receptors. It has been detected in commercially-available herbal products. JWH 122 3-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 3, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

05-16 · JWH 122 5-methylnaphthyl isomer

Wed, 16 May 2012 00:00:00 EDT

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both central cannabinoid (CB1) (Ki = 0.69 nM) and peripheral cannabinoid (CB2) (Ki = 1.2 nM) receptors. It has been detected in commercially-available herbal products. JWH 122 5-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 5, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

05-16 · JWH 122 6-methylnaphthyl isomer

Wed, 16 May 2012 00:00:00 EDT

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both CB1 (Ki = 0.69 nM) and CB2 (Ki = 1.2 nM) receptors. It has been detected in commercially-available herbal products. JWH 122 6-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 6, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

05-16 · JWH 122 7-methylnaphthyl isomer

Wed, 16 May 2012 00:00:00 EDT

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both CB1 (Ki = 0.69 nM) and CB2 (Ki = 1.2 nM) receptors. It has been detected in commercially-available herbal products. JWH 122 7-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 7, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

05-16 · JWH 122 8-methylnaphthyl isomer

Wed, 16 May 2012 00:00:00 EDT

JWH 122 is a synthetic cannabinoid (CB) that displays high-affinities for both central cannabinoid (CB1) (Ki = 0.69 nM) and peripheral cannabinoid (CB2) (Ki = 1.2 nM) receptors. It has been detected in commercially-available herbal products. JWH 122 8-methylnaphthyl isomer differs from JWH 122 in that the methyl group is attached to the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

05-16 · Oleanolic Acid

Wed, 16 May 2012 00:00:00 EDT

Oleanolic acid is a triterpenoid that is synthesized in many plants by the cyclization of squalene. Traditionally used in Asian medicine, oleanolic acid has long been known to have anti-inflammatory, anti-hyperlipidemic, and hepatoprotective in vivo effects. It has also been found to have antiviral and anti-tumor actions. Synthetic triterpenoids based on oleanolic acid have been shown to bind specific proteins by Michael addition. Important protein targets include Keap1, IKK, JAK1, STAT3, PTEN, and proteins associated with the actin cytoskeleton.

05-16 · Salvinorin A

Wed, 16 May 2012 00:00:00 EDT

Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM).

05-15 · AM1220 azepane isomer

Tue, 15 May 2012 00:00:00 EDT

AM1220 is a synthetic cannabinoid (CB) with preference for the central CB1 receptor (Ki = 3.88 nM) over the peripheral CB2 receptor (Ki = 73.4 nM). AM1220 azepane isomer is an isomer of AM1220 in which the piperidine group has been replaced with azepane. The physiological and toxicological properties of this compound have not been explored. This product is intended for forensic and research applications.

05-15 · AM2201 2-hydroxyindole metabolite

Tue, 15 May 2012 00:00:00 EDT

AM2201 is a potent synthetic cannabinoid (CB) with Ki values of 1.0 and 2.6 nM for the central (CB1) and peripheral (CB2) receptors, respectively. AM2201 2-hydroxyindole metabolite is a potential monohydroxylated urinary metabolite of AM2201, based on the known metabolism of similar compounds. Its biological actions are unknown.

05-09 · IOX1

Wed, 09 May 2012 00:00:00 EDT

2-oxoglutarate (2OG) and other Fe(II)-dependent oxygenases are an important family of enzymes with roles in collagen biosynthesis, lipid metabolism, nucleic acid repair and modification, histone demethylation, and hypoxic sensing. Impaired 2OG oxygenase activity is linked to the cellular hypoxic response and various diseases including cancer. Iron-chelators, Co(II) ions, and 2OG analogues such as pyridine-2,4-dicarboxylate and N-oxalylglycine have been used as non-selective inhibitors of 2OG oxygenases. However, they require administration as pro-drug diester derivatives. IOX1 is a broad-spectrum inhibitor of 2OG oxygenases that does not require application in a pro-drug formulation. IOX1 inhibits JMJD2A, JMJD2E and the 2OG oxygenases PHF8, PHD2, and FIH with IC50 values of 1.7, 2.4 13.3, 14.3 and 20.5 μM, respectively. IOX1 inhibits H3K9me3 demethylation by JMJD2A in HeLa cells with an IC50 value of 87 μM. See for more information.

05-09 · Telmisartan

Wed, 09 May 2012 00:00:00 EDT

Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM). It also acts as a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.

05-08 · AM2233 azepane isomer

Tue, 08 May 2012 00:00:00 EDT

AM2233 is a synthetic cannabinoid (CB) which acts as a full agonist of the central (CB1) receptor (Ki = 2.8 nM). AM2233 azepane isomer is an isomer of AM2233 in which the piperidine group has been replaced with azepane. The physiological and toxicological properties of this compound have not been explored. This product is intended for forensic and research applications.

05-08 · Glipizide

Tue, 08 May 2012 00:00:00 EDT

Glipizide is a short-acting, second-generation, blood-glucose-lowering agent belonging to the sulfonylurea class that increases the release of endogenous insulin from β-cells by blocking potassium channels. Glipizide is most commonly used to lower blood sugar levels in type II diabetes (non-insulin-dependent diabetes mellitus). It is a weak acid (pKa = 5.9) that is better absorbed in acidic medium. However, its aqueous solubility is limited at very low pH values, causing large variations in bioavailability.

05-08 · JMJD2A-Strep tagged (human recombinant)

Tue, 08 May 2012 00:00:00 EDT

Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of tri- and di-methylated forms of histone H3 at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an α-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. JMJD2A’s transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.

05-08 · JMJD2D-Strep tagged (human recombinant)

Tue, 08 May 2012 00:00:00 EDT

Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residues 9 and 27 (me 2/3), leading to transcriptional repression and activation, respectively. Like other JmjC protein hydroxylase family members, JMJD2D is an α-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.

05-08 · JMJD2E-Strep tagged (human recombinant)

Tue, 08 May 2012 00:00:00 EDT

Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2E (JMJD2E) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residues 9 and 27 (me 2/3), leading to transcriptional repression and activation, respectively. Like other JmjC protein hydroxylase family members, JMJD2E is an α-ketoglutate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity, therefore this this Strep-tagged protein is purified by affinity chromatography using Strep-Tactin coated resin. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.