Cayman Chemical New Products

02-10 · 2-Ethylethcathinone (hydrochloride)

Fri, 10 Feb 2012 00:00:00 EST

Substituted cathinones, like ethcathinone, are psychoactive compounds commonly used as recreational drugs. Some have amphetamine-like effects. 2-Ethylethcathinone (hydrochloride) is a substituted cathinone with potential for abuse. Its biological and toxicological properties have not been evaluated. This product is intended for forensic and research applications.

02-10 · 3-Fluoromethamphetamine (hydrochloride)

Fri, 10 Feb 2012 00:00:00 EST

4-Fluoromethamphetamine (4-FMA) is a stimulant drug related to methamphetamine and 4-fluoroamphetamine. It has been identified as a component of designer drugs sold as bath salts or powders. 3-Fluoromethamphetamine (hydrochloride) is an isomer of 4-FMA characterized by having fluorine at the 3 position of the phenyl group. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

02-10 · JWH 249

Fri, 10 Feb 2012 00:00:00 EST

JWH 249 is a synthetic cannabinoid (CB) that potently activates the central CB1 and peripheral CB2 receptors (Ki = 8.4 and 20 nM, respectively). The properties of this compound in vivo have not been characterized. This product is intended for forensic and research purposes.

02-09 · 2-Fluoromethamphetamine (hydrochloride)

Thu, 09 Feb 2012 00:00:00 EST

2-Fluoromethamphetamine (2-FMA) is a stimulant drug related to methamphetamine and 2-fluoroamphetamine. Though little is known of the pharmacological properties of fluoro-methoxy-substituted amphetamines, 2-FMA has been identified as a component of designer drugs sold as “legal high” replacements for restricted substances. The hydrochloride formulation of this compound is intended for use as a standard for the forensic analysis of samples that may contain 2-FMA.

02-09 · 2-Methylmethcathinone (hydrochloride)

Thu, 09 Feb 2012 00:00:00 EST

4-Methylmethcathinone (4-MMC) is a psychoactive synthetic cathinone that has been identified in bath salts and powders. 2-MMC (hydrochloride) is a potential major impurity in preparations of 4-MMC. As an isomer of 4-MMC, it is likely to have psychoactive properties and may itself be marketed as a designer drug. The physiological and toxicological properties of this compound have not been determined. This product is intended for forensic and research applications.

02-09 · JWH 175

Thu, 09 Feb 2012 00:00:00 EST

JWH 175 is a synthetic cannabinoid (CB) that potently activates the central CB1 receptor (Ki = 22 nM). As a naphthylmethylindole, it is structurally related to JWH 018. The properties of this compound at the peripheral CB2 receptor or in vivo have not been characterized. This product is intended for forensic and research purposes.

02-08 · 11-dehydro Thromboxane B2 EIA Kit - Monoclonal

Wed, 08 Feb 2012 00:00:00 EST

Thromboxane A2 (TXA2), produced from arachidonic acid, causes irreversible platelet aggregation, vascular, and bronchial smooth muscle contraction. TXA2 is rapidly hydrolyzed non-enzymatically to form TXB2. However, most of the TXB2 measured in the plasma or urine of healthy individuals is due to ex vivo platelet activation or intra-renal production, and normal concentrations of circulating TXB2 are extremely low (1-2 pg/ml) and highly transient (t1/2 = 5-7 minutes). 11-dehydro TXB2 is a metabolite of TXB2 (not formed by platelets or the kidney) with a circulating half-life (t1/2) of 45 minutes. Its measurement in plasma or urine will give a time-integrated indication of TXA2 production and is recommended to estimate TXA2 levels to circumvent measurement complications associated with TXB2. Cayman's 11-dehydro TXB2 EIA Kit is a competitive assay that can be used for quantification of 11-dehydro TXB2 in urine and other sample matrices. Normal plasma levels of 11-dehydro TXB2 (1-2 pg/ml) are below the detection limit of this assay (16 pg/ml), so plasma samples must be purified and concentrated prior to analysis. Urine samples should be diluted appropriately before assaying. There is evidence suggesting that 11-dehydro TXB2 can be formed non-enzymatically following platelet activation, so it is important to process plasma samples quickly to prevent artifactual formation of 11-dehydro TXB2. The EIA typically displays an IC50 (50% B/B0) value of 120 pg/ml and a detection limit (80% B/B0) of approximately 34 pg/ml.

02-08 · 25-hydroxy Cholesterol

Wed, 08 Feb 2012 00:00:00 EST

25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types. It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases. Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.

02-07 · 2-Fluoroamphetamine (hydrochloride)

Tue, 07 Feb 2012 00:00:00 EST

Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters. 2-FA (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 2, rather than the 4, position. The physiological and toxicological properties of 2-FA are not known. This product is intended for research and forensic applications.

02-07 · 3-Fluoroamphetamine (hydrochloride)

Tue, 07 Feb 2012 00:00:00 EST

Halogenated amphetamines, including 4-fluoroamphetamine (4-FA), are psychostimulatory designer drugs which inhibit the uptake of monoamine neurotransmitters. 3-Fluoroamphetamine (hydrochloride) is a structural isomer of 4-FA, having the fluorine at the 3, rather than the 4, position. The physiological and toxicological properties of 3-FA are not known. This product is intended for research and forensic applications.

02-07 · DMABA-d6 NHS ester

Tue, 07 Feb 2012 00:00:00 EST

DMABA-d6 NHS ester is intended for use in combination with DMABA NHS ester (Item No. 11216) as a derivatizing reagent for PE lipids in order to facilitate MS characterization and to quantify relative changes in their abundance. DMABA-d6 and DMABA NHS esters have been shown to facilitate the characterization of PE lipids via electrospray mass spectrometry by providing a common precursor ion scan for diacyl, ether, and plasmalogen PE lipids. Furthermore, application of split-and-pool methodology allows for relative changes in endogenous PE lipid levels between control and treated samples to be measured. Phosphatidylethanolamine (PE) lipids are important components of cell membranes and biochemical pathways of fatty acid synthesis that contain abundant polyunsaturated fatty acyl groups. Oxidation of these phospholipids may be linked to various human diseases. DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. This facilitates the use of electrospray tandem mass spectrometry for the detection of diacyl, ether, and plasmalogen PE lipids that cannot be readily observed otherwise.

02-06 · 25I-NMBOMe

Mon, 06 Feb 2012 00:00:00 EST

The serotonin 2A (5-HT2A) receptor is expressed at high density within the frontal cortex, but at lower levels in many other brain areas. It has been implicated in working memory, cognitive processes, affective disorders such as schizophrenia, and mediates the primary effects of hallucinogenic drugs. 25I-NMBOMe, a derivative of the phenethylamine hallucinogen 2C-I, is a highly potent agonist for the human 5-HT2A receptor with a Ki value of 0.044 nM, making it 16-fold more potent than 2C-I. A radiolabelled form of 25I-NBOMe has been used for mapping the distribution of 5-HT2A receptors in the brain.

02-06 · 2-Methoxymethcathinone (hydrochloride)

Mon, 06 Feb 2012 00:00:00 EST

Methedrone (Item No. 10529), also known as 4-methoxymethcathinone, is a psychoactive compound that has been identified as an adulterant of party pills and bath salts. 2-Methoxymethcathinone (hydrochloride) is a positional isomer of methedrone, having the methoxy group at the 2 rather than the 4 position. It is also the β-keto derivative of 2-methoxymethamphetamine, a β-adrenergic receptor agonist used as a bronchodilator. The properties of 2-methoxymethcathinone have been poorly studied. This product is intended for forensic and research applications.

02-06 · 3-Methylethcathinone (hydrochloride)

Mon, 06 Feb 2012 00:00:00 EST

Substituted cathinones, like 4-methylethcathinone (Item No. 9001069) and 3,4-dimethylmethcathinone (Item No. 9001098) are psychoactive compounds that may be used as designer drugs. 3-Methylethcathinone (hydrochloride) is a substituted cathinone with potential for abuse. Its biological properties have not been elucidated. This product is intended for forensic and research applications.

02-06 · 4-Methylbenzylidene camphor

Mon, 06 Feb 2012 00:00:00 EST

4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities. It has estrogenic activity in fish and in mammals, binding competitively to estrogen receptors and stimulating transactivation. In addition to reducing receptor sensitivity to estradiol, 4-MBC directs dose-dependent changes in the expression of estrogen receptor subtypes, progesterone receptor, and androgen receptor. This results in changes in reproductive organ and brain development in both males and females. When applied topically, it is absorbed systemically and can be detected in urine.

02-06 · AM1248

Mon, 06 Feb 2012 00:00:00 EST

AM1248 is an adamantoylindole derivative with an N-methylpiperidin-2-ylmethyl substitution at the indole 1-position. It reportedly acts as a moderately potent agonist for both the central CB1 and peripheral CB2 cannabinoid receptors (Kis = 11.9 and 4.8 nM, respectively). A related compound, 1-pentyl-3-(1-adamantoyl)indole, along with another synthetic cannabinoid, AM679, was identified as having been sold as a cannabinoid herbal blend known as “smart products” in Hungary in 2011.

02-06 · SB 939

Mon, 06 Feb 2012 00:00:00 EST

Inhibition of histone deacetylases (HDACs) leads to accumulation of acetylated histones, resulting in a variety of cell type-dependent responses including apoptosis, necrosis, differentiation, cell survival, inhibition of proliferation, and cytostasis. SB 939 is an HDAC inhibitor that displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay and prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT-116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.56, 0.48, and 0.34 μM, respectively. SB 939 is a pan-HDAC inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg. It is being evaluated in phase I and phase II clinical trials in both hematological and solid tumor patients.

02-03 · 3-Fluoroethcathinone (hydrochloride)

Fri, 03 Feb 2012 00:00:00 EST

Fluorine-substituted cathinones, including 3-fluoromethcathinone (Item No. 10730), are psychoactive cathinone derivatives that have been identified in designer drugs marketed as bath salts, plant food, or pills. 3-Fluoroethcathinone (hydrochloride) is a fluorine-substituted synthetic cathinone that has potential for abuse. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.

02-03 · 3-Methylmethcathinone (hydrochloride)

Fri, 03 Feb 2012 00:00:00 EST

4-Methylmethcathinone (4-MMC) is a psychoactive synthetic cathinone that has been identified in bath salts and powders. 3-Methylmethcathinone (hydrochloride) is a potential major impurity in preparations of 4-MMC. As an isomer of 4-MMC, it is likely to have psychoactive properties and may itself be marketed as a designer drug. The physiological and toxicological properties of this compound have not been determined. This product is intended for forensic and research applications.

02-03 · Meconin

Fri, 03 Feb 2012 00:00:00 EST

Meconin, a noscapine metabolite, is a urinary detection marker for illicit opiate misuse. This product is intended for use as a forensic standard.