Cayman Chemical Screen Saver

02-22 · Ascomycin

02-22 · Beauvericin

Beauvericin is a mycotoxin originally derived from Beauveria bassiana, a common fungal parasite of arthropods. It is also produced by the fungus Fusarium, a pathogen of insects and plants. Beauvericin is cytotoxic against insect cells, killing the insect cell line SF-9 with a 50% cytotoxic concentration of 2.5 μM. In mammalian cells, beauvericin induces apoptosis with an IC50 of 4.5 μM.

02-22 · BSI-201

02-22 · Cytochalasin B

02-22 · Diacetoxyscirpenol

02-22 · Fumagillin

02-22 · Phenylpiperazine (hydrochloride)

Phenylpiperazine is the base compound from which a broad series of bioactive products are derived. Many are entactogenic drugs which induce central serotonin release. Substituted phenylpiperazines, such as 1-(3-chlorophenyl)piperazine, have been identified as designer drugs or drugs of abuse. This product is intended for forensic applications.

02-22 · Thiolutin

02-22 · Zearalenone

02-21 · 1-(m-Trifluoromethylphenyl) piperazine (hydrochloride)

1-(m-Trifluoromethylphenyl) piperazine (TFMPP) is an entactogenic drug which selectively promotes the release of serotonin. When used in combination with 1-benzylpiperazine, TFMPP increases both serotonin and dopamine, mirroring the effects of 3,4-methylenedioxymethamphetamine. Drug-drug synergism may induce seizures. TFMPP has been identified in party pills and powders. Its metabolism in rats has been described. This product is intended for forensic applications.

02-21 · Citrinin

Citrinin is a mycotoxin originally isolated from Penicillium citrinum that is also produced by a variety of other fungi that are found as contaminants in human foodstuffs and animal feeds. Citrinin exerts cytotoxic and genotoxic effects in various mammalian cells, causing mycotoxic nephropathy in livestock and Balkan nephropathy and yellow rice fever in humans. Because citrinin induces apoptosis and blocks tubulin polymerization as well as mitotic spindle assembly, it is useful as a biological research reagent.

02-21 · Docosahexaenoyl Ethanolamide-d4

Docosahexaenoyl ethanolamide-d4 contains four deuterium atoms at the 1, 1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of docosahexaenoyl ethanolamide by GC- or LC-mass spectrometry (MS). Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for arachidonoyl ethanolamide (AEA). A 9.5 fold increase of DHEA was observed in brain lipid extracts from piglets fed a diet supplemented with DHA compared to a control diet without DHA. DHEA binds to the rat brain CB1 receptor with a Ki of 324 nM, which is approximately 10-fold higher than the Ki for AEA. DHEA inhibits shaker-related voltage-gated potassium channels in brain slightly better than AEA, with an IC50 of 1.5 µM.

02-21 · Ercalcitriol

Ercalcitriol is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D -hydroxylase in the kidney. By binding to the vitamin D receptor (VDR), ercalcitriol activates VDR to interact with the retinoid X receptor (RXR), forming the VDR/RXR/cofactor complex, which regulates gene transcription. Because ercalcitriol circulates at picomolar concentrations and is highly lipophilic, it is difficult to quantify.

02-20 · 1-(4-Fluorobenzyl) piperazine (hydrochloride)

Benzylpiperazines (BZP) are stimulant drugs which inhibit monoamine uptake. BZP and substituted derivatives, such as 1-(3,4-methylenedioxybenzyl)piperazine (MDBP), have been identified as designer drugs or drugs of abuse. 1-(4-Fluorobenzyl) piperazine is a substituted BZP with a potential for abuse. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications. 1-(4-Fluorobenzyl) piperazine is also used as a precursor in the synthesis of certain bioactive compounds.

02-20 · 1-(p-Fluorophenyl) piperazine (hydrochloride)

Phenylpiperazines are entactogenic drugs which direct central serotonin release. Substituted phenylpiperazines, such as 1-(3-chlorophenyl)piperazine, have been identified as designer drugs or drugs of abuse. 1-(p-Fluorophenyl) piperazine (hydrochloride) is a substituted phenylpiperazine with a potential for abuse. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.

02-20 · 3,4-Dimethoxymethamphetamine (hydrochloride)

3,4-Dimethoxymethamphetamine (hydrochloride) (DMMA) is an analog of 3,4-methylenedioxymethamphetamine (MDMA), a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. DMMA appears to interfere with monoamine transport, inhibiting uptake of noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM and IC50s = 253.4 and 108 μM, respectively). DMMA is significantly less potent than MDMA (Kis = 0.6 and 2.5 μM and IC50s = 6.6 and 34.8 μM for MDMA inhibition of noradrenalin and serotonin transporters, respectively).

02-20 · Cyclopamine

Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of action, cyclopamine inhibits hedgehog-dependent expression of Pax7 with an IC50 value of 24 nM. Although teratogenic during development, cyclopamine has potential applications in the treatment of cancer.

02-20 · Diethylcathinone (hydrochloride)

Diethylcathinone is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant. It functions as an inactive prodrug that only becomes active when further metabolized to ethcathinone, a selective norepinephrine releasing agent. In the US, diethylcathinone is classified as a Schedule IV controlled substance, with low potential for abuse.

02-17 · 4-Methyl-α-pyrrolidinobutiophenone (hydrochloride)

4-Methyl-α-pyrrolidinobutiophenone (MPBP) is a synthetic cathinone with psychoactive properties which has recently been identified in party pills and powders. The metabolism of MPBP has been characterized. The biological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.

02-17 · JWH 031

JWH 031 is a synthetic cannabinoid (CB) with a relatively low binding affinity for the central CB1 receptor (Ki = 399 nM). Despite its low affinity for CB1, this pyrrole-based cannabinoid is efficacious in reducing spontaneous activity and increasing antinociception in mice. This product is intended for forensic and research applications.