For immunochemical analysis of eIF4A2

Antigen: synthetic peptide from human eIF4A2 within the region of amino acids 50-100 · Host: rabbit · Application(s): WB ·

A fluorescence-based tool for quantifying ascorbate from plasma, serum, urine, and fruit juices

Ascorbate (L-Ascorbic acid or Vitamin C) is a six-carbon lactone that is synthesized from glucose in the liver of most mammalian species, but not by humans. Therefore, humans must obtain ascorbate in their diet in order to survive. In humans, ascorbate acts as an electron donor for eight different enzymes. It also serves as an antioxidant and may be beneficial for reducing the risk of developing chronic diseases such as cancer, cardiovascular disease, and cataracts. Cayman’s Ascorbate Assay provides a reproducible, sensitive fluorescence-based tool for quantifying ascorbate from plasma, serum, urine, and fruit juices.

A synthetic cannabinoid urinary metabolite

JWH 018 4-hydroxyindole metabolite is a major monohydroxylated urinary metabolite of JWH 018, a WIN 55,212-2 derivative that is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor. In urine samples, this metabolite is almost completely glucuronidated.

A synthetic cannabinoid urinary metabolite

JWH 018 5-hydroxyindole metabolite is a major monohydroxylated urinary metabolite of JWH 018, a WIN 55,212-2 derivative that is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor. In urine samples, this metabolite is almost completely glucuronidated.

A synthetic cannabinoid urinary metabolite

JWH 018 6-hydroxyindole metabolite is a minor monohydroxylated urinary metabolite of JWH 018, a WIN 55,212-2 derivative that is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor.

A synthetic cannabinoid urinary metabolite

JWH 018 7-hydroxyindole metabolite is a minor monohydroxylated urinary metabolite of JWH 018, a WIN 55,212-2 derivative that is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor.

Urinary metabolite of synthetic cannabinoid JWH 018

JWH 018 metabolite 5 is a major urinary metabolite of JWH 018, characterized by monohydroxylation of the N-alkyl chain. In urine samples, this metabolite is almost completely glucuronidated.

Urinary metabolite of synthetic cannabinoid JWH 018

JWH 018 Metabolite 6 is a minor urinary metabolite of JWH 018, characterized by carboxylation of the N-alkyl chain. In urine samples, this metabolite is almost completely glucuronidated.

A synthetic cannabinoid urinary metabolite

JWH 073 4-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018.

A synthetic cannabinoid urinary metabolite

JWH 073 5-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018.

A synthetic cannabinoid urinary metabolite

JWH 073 6-hydroxyindole metabolite is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018.

A synthetic cannabinoid urinary metabolite

JWH 073 7-hydroxyindole metabolite, is expected to be a urinary metabolite of JWH 073 based on the metabolism of the closely-related JWH 015 and JWH 018.

Urinary metabolite of synthetic cannabinoid JWH 073

JWH 073 N-(5-hydroxybutyl) metabolite is expected to be a major urinary metabolite of JWH 073, characterized by monohydroxylation of the N-alkyl chain, based on the metabolism of the closely-related JWH 015 and JWH 018. In urine samples, this metabolite of JWH 018 is almost completely glucuronidated.

Urinary metabolite of synthetic cannabinoid JWH 073

JWH 073 N-butanoic acid metabolite is expected to be a urinary metabolite of JWH 073, characterized by carboxylation of the N-alkyl chain, based on the metabolism of the closely-related JWH 015 and JWH 018. In urine samples, this metabolite of JWH 018 is almost completely glucuronidated.

For immunochemical analysis of eIF4A2

Antigen: synthetic peptide from human eIF4A2 within the region of amino acids 1-50 · Host: rabbit · Application(s): IHC (paraffin embedded-sections) and WB ·

A competitive assay used for quantification of CysLT

Limit of detection: 80% B/B₀: 34 pg/ml · Sensitivity: 50% B/B₀: 103 pg/ml · Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid via the 5-lipoxygenase (5-LO) pathway in leukocytes. LTC₄, LTD₄, and LTE₄ are collectively referred to as cysteinyl leukotrienes (CysLTs). LTC₄ and LTD₄ are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. The biological activity of LTE₄ is much lower in most systems studied, but its presence reflects the prior existence of LTC₄ and LTD₄. Cayman’s CysLT EIA Kit is a competitive assay based on a proprietary high-affinity monoclonal antibody that can be used for quantification of CysLT in urine and other sample matrices. The EIA typically displays an IC₅₀ (50% B/B₀) of approximately 103 pg/ml and a detection limit (80% B/B₀) of approximately 34 pg/ml.

An internal standard for the quantification of oleic acid

Oleic acid-d17 contains 17 deuterium atoms at the 11, 11’, 12, 12’, 13, 13’, 14, 14’, 15, 15’, 16, 16’, 17, 17’, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of oleic acid by GC- or LC-mass spectrometry.

A fluorescence-based method for detecting uric acid in serum, plasma, and urine

Uric acid (urate) is the end product of human purine metabolism and is mainly excreted in urine. Many factors, including genetic components and acquired factors, such as obesity and alcohol consumption, influence serum uric acid concentrations. Hyperuricemia induces or facilitates gout, kidney stones, metabolic syndrome, hypertension, and renal and cardiovascular disease, while exercise-induced acute renal failure is a significant complication of renal hypouricemia. Cayman’s Uric Acid Assay provides a fluorescence-based method for detecting uric acid in serum, plasma, and urine.

A dual PI3Kα/mTOR kinase inhibitor

CAY10626 is a potent, dual PI3Kα/mTOR inhibitor with IC₅₀ values of 0.9 and 0.6 nM for the two respective kinases. In a tumor cell growth inhibition assay, CAY10626 demonstrates IC₅₀ values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. When administered at 25-50 mg/k to MD361 xenograft mice, phosphorylation of the downstream targets of PI3Kα and mTOR (Akt T308, Akt S473, and S6K) was suppressed, and significant tumor regression was observed.

A deuterated form of CEP-lysine

CEP-Lysined4 contains four deuterium atoms at the carboxyethyl 1,1',2,2' positions. It is intended for use as an internal standard for the quantification of CEP-lysine by GC- or LC-mass spectrometry (MS).

A potent mitotic inhibitor

Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC₅₀ values ranging from 2.5-7.5 nM.{Liebmann} Paclitaxel disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC₅₀s = 6.7-18.5 nM) at both prophase and G₁. It initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.

Phosphatidyl inositol trisphosphate containing DHA

PtdIns-(3,4,5)-P₃ (1-stearoyl, 2-docosahexaenoyl is an uncommon phospholipid having the ω-3 fatty acid docosahexaenoate (DHA) in the sn-2 position. In addition to releasing an unusual DHA-containing DAG in response to PLC, this phospholipid can serve as a source of DHA in response to phospholipases A₂ (PLA₂). Importantly, the inositol head group of PtdIns-(3,4,5)-P₃ can serve as an anchor for the binding of proteins bearing pleckstrin homology (PH) domains.

15 Carbon sphingosine

D-erythro-Sphingosine C-15 is a naturally-occurring but rare form of sphingosine. It is intended to be used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.

17 Carbon sphingosine

D-erythro-Sphingosine C-17 is a naturally-occurring but uncommon form of sphingosine, accounting for approximately 13% of the sphingosine in human skin. It can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate. More commonly, sphingosine C-17 is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.

Antioxidant, precursor of vitamin A

β-Carotene is a red/orange-colored fat-soluble terpenoid with antioxidant properties. It can be enzymatically cleaved to produce vitamin A and retinoic acid. Vitamin A is important for vision and bone growth, while retinoic acid, through the retinoic acid receptor, plays an important role in cell differentiation.