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β-Catenin Polyclonal Antibody

Cayman Chemical Item Number 100029

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Description

Antigen: human β-catenin amino acids 43-62 (APSLSGKGNPEEEDVDTSQV) · Host: rabbit · Application(s): WB and IHC · β-Catenin is a multifunctional protein known to be part of the Wnt pathway, playing essential roles in development and carcinogenesis.1,2,3 β-Catenin can act as a regulator of the cell cycle and apoptosis in a variety of different cell systems.4,5 The entire primary amino acid sequence is identical among human, rat, and mouse, indicating critical functions of this protein6,7,8. Cayman Chemical’s β-catenin polyclonal antibody can be used for Western blot and immunohistochemical (formalin-fixed paraffin-embedded tissue) analysis of β-catenin on samples of human, murine, rat, porcine and bovine origin. Use of this antibody for other species and applications has not yet been tested.

1 Yano, H., Hara, A., Takenaka, K., et al. Differential expression of β-catenin in human glioblastoma multiforme and normal brain tissue. Neurol Res 22 650-656 (2000).

2 Haq, S., Michael, A., Andreucci, M., et al. Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci USA 100(8) 4610-4615 (2003).

3 Yasui, K., Li, G., Wang, Y., et al. β-Catenin in early development of the lancelet embryo indicates specific determination of embroyonic polarity. Dev Growth Differ 44 467-475 (2002).

4 Olmeda, D., Castel, S., Vilaró, S., et al. β-catenin regulation during the cell cycle: Implications in G2/M and apoptosis. Mol Biol Cell 14 2844-2860 (2003).

5 Jaiswell, A.S., Marlow, B.P., Gupta, N., et al. β-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21 8414-8427 (2002).

6 Aberle, H., Butz, S., Stappert, J., et al. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci 107 3655-3663 (1994).

7 Chung, S.S.W., Lee, W.M., and Cheng, C.Y. Study on the formation of specialized inter-sertoli cell junctions in vitro. J Cell Physiol 181 258-272 (1999).

8 Nollet, F., Berx, G., Molemans, F., et al. Genomic organization of the human β-catenin gene (CTNNB1). Genomics 32 413-424 (1996).

Formulation Peptide affinity-purified IgG
Stability 6 months
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
Size Price Quantity Subtotal
500 µl $229.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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