100029  β-Catenin Polyclonal Antibody
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• See more Immunohistochemistry; Western Blot; Antibodies; Cancer

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Antigen: human β-catenin amino acids 43-62 (APSLSGKGNPEEEDVDTSQV) · Host: rabbit · Application(s): WB and IHC · β-Catenin is a multifunctional protein known to be part of the Wnt pathway, playing essential roles in development and carcinogenesis.1,2,3 β-Catenin can act as a regulator of the cell cycle and apoptosis in a variety of different cell systems.4,5 The entire primary amino acid sequence is identical among human, rat, and mouse, indicating critical functions of this protein6,7,8. Cayman Chemical’s β-catenin polyclonal antibody can be used for Western blot and immunohistochemical (formalin-fixed paraffin-embedded tissue) analysis of β-catenin on samples of human, murine, rat, porcine and bovine origin. Use of this antibody for other species and applications has not yet been tested.
1  Yano, H., Hara, A., Takenaka, K., et al. Differential expression of β-catenin in human glioblastoma multiforme and normal brain tissue. Neurol Res 22 650-656 (2000).
2  Haq, S., Michael, A., Andreucci, M., et al. Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth. Proc Natl Acad Sci USA 100(8) 4610-4615 (2003).
3  Yasui, K., Li, G., Wang, Y., et al. β-Catenin in early development of the lancelet embryo indicates specific determination of embroyonic polarity. Development Growth Differ 44 467-475 (2002).
4  Olmeda, D., Castel, S., Vilaró, S., et al. β-catenin regulation during the cell cycle: Implications in G2/M and apoptosis. Molecular Biology of the Cell 14 2844-2860 (2003).
5  Jaiswell, A.S., Marlow, B.P., Gupta, N., et al. β-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21 8414-8427 (2002).
6  Aberle, H., Butz, S., Stappert, J., et al. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci 107 3655-3663 (1994).
7  Chung, S.S.W., Lee, W.M., Cheng, C.Y. Study on the formation of specialized inter-sertoli cell junctions in vitro. J Cell Physiol 181 258-272 (1999).
8  Nollet, F., Berx, G., Molemans, F., et al. Genomic organization of the human β-catenin gene (CTNNB1). Genomics 32 413-424 (1996).


Purchase 100029 β-Catenin Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-15.
Prices are subject to change without notice.

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