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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Endothelial Lipase (human) Blocking Peptide

Cayman Chemical Item Number 10004111

EDL; EL

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Description

Peptide sequence: amino acids 19-32 (AGSPVPFGPEGRLE) · To be used in conjunction with Cayman’s endothelial lipase polyclonal antibody (Catalog No. 100030) to block protein-antibody complex formation during analysis for the endothelial lipase · Endothelial lipase (EL) is a member of the triglyceride lipase gene family. It functions primarily as a phospholipase and has low triglyceride lipase activity. It has been shown to be a major genetic determinant for concentration, structure, and metabolism of high-density lipoprotein, which protects against atherosclerosis. 1,2 It was originally cloned from endothelial cells and was found to be expressed in a distinct and complementary tissue-restricted fashion, with high-level expression in the liver, placenta, lung, ovary, placenta, and macrophage.3 The wide spread distribution of this protein suggests that it plays a general role in lipid metabolism. Immunohistochemical studies demonstrate that EL is expressed in infiltrating cells such as macrophages within atheromatous plaques, in addition to endothelial and smooth muscle cells in non-atherosclerotic coronary arteries. Furthermore, EL expression is detected in the neovasculature within atheromatous plaques in atherosclerotic coronary arteries, indicating that EL may have unique functional roles in atherosclerosis.4 Human endothelial lipase has an estimated molecular weight of 57 kDa.

1 Ishida, T., Choi, S., Kundu, R.K., et al. Endothelial lipase is a major determinant of HDL level. J Clin Invest 111(3) 347-355 (2003).

2 Ma, K., Cilingiroglu, M., Otvos, J.D., et al. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci USA 100(5) 2748-2753 (2003).

3 Hirata, K., Dichek, H.L., Cioffi, J.A., et al. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 274(20) 14170-14175 (2003).

4 Azumi, H., Hirata, K., Ishida, T., et al. Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Cardiovasc Res 58 647-654 (2003).

Synonyms
  • EDL
  • EL
Formulation 200 µg of peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Size Price Quantity Subtotal
200 µg $107.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Endothelial Lipase Polyclonal Antibody

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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