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Luteolin

Cayman Chemical Item Number 10004161

(CAS 491-70-3)

Luteolin (CAS 491-70-3)

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Description

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets.1 Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves.2 Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM.3 Luteolin has also been found to inhibit the release of TNFα from neutrophils, and to inhibit matrix metalloproteinases.4

1 Morton, L.W., Caccetta, R.A., Puddey, I.B., et al. Chemistry and biological effects of dietary phenolic compounds: Relevance to cardiovascular disease. Clin Exp Pharmacol Physiol 27 152-159 (2000).

2 Ueda, H., Yamazaki, C., and Yamazaki, M. Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Biol Pharm Bull 25(9) 1197-1202 (2002).

3 Sadik, C.D., Sies, H., and Schewe, T. Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action. Biochem Pharmacol 65 773-781 (2003).

4 Sartor, L., Pezzato, E., Dell'Aica, I., et al. Inhibition of matrix-proteases by polyphenols: Chemical insights for anti-inflammatory and anti-invasion drug design. Biochem Pharmacol 64 229-237 (2002).

Formal Name 2-​(3,​4-​dihydroxyphenyl)-​5,​7-​dihydroxy-​4H-​1-​benzopyran-​4-​one
CAS Number 491-70-3
Molecular Formula C15H10O6
Formula Weight 286.2
Formulation A crystalline solid
Purity >98%
λmax 255, 348 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1cc(O)​c2c(=O)​cc(oc2c1)​c1ccc(O)​c(O)​c1

Luteolin is available in the following screening library:

Size Price Quantity Subtotal
10 mg $12.00 $0.00
50 mg $54.00 $0.00
100 mg $96.00 $0.00
500 mg $420.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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