See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10443

Cayman Chemical Item Number 10004177

(S)-Indan-1-yl 3,4-dichlorobenzylcarbamate (CAS 582314-48-5)

CAY10443 (CAS 582314-48-5)

See more

Description

Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome.1 Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 value of 5 µM.2 These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.

1 Cecconi, F., Alvarez-Bolado, G., Meyer, B.I., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94 727-737 (1998).

2 Nguyen, J.T., and Wells, J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci USA 100(13) 7533-7538 (2003).

Synonyms
  • (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate
Formal Name (1S)-​2,​3-​dihydro-​1H-​inden-​1-​yl ester [(3,​4-​dichlorophenyl)methyl]-​carbamic acid
CAS Number 582314-48-5
Molecular Formula C17H15Cl2NO2
Formula Weight 336.1
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C(NCc1ccc(Cl)​c(Cl)​c1)​O[C@H]​1CCc2ccccc12

CAY10443 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $10.00 $0.00
5 mg $45.00 $0.00
10 mg $80.00 $0.00
50 mg $350.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Apaf-1 Polyclonal Antibody
Caspase-3 (human) Polyclonal Antibody
Caspase-9 Polyclonal Antibody
F16
PRIMA-1
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?