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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

NESS 0327 Exclusive

Cayman Chemical Item Number 10004184

(CAS 494844-07-4)

NESS 0327 (CAS 494844-07-4)

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Description

NESS 0327 is an extremely potent cannabinoid (CB) receptor antagonist with high selectivity for the CB1 receptor compared to the CB2 receptor with Ki values of 0.35 pM and 21 nM, respectively.1 It is a much more potent antagonist and more selective for the CB1 receptor compared to SR 141716A (rimonabant). At nM concentrations NESS 0327 competitively inhibits the binding of the synthetic CB agonist WIN 55,212-2 in isolated rat cerebella membranes and murine vas deferens.1,2 Unlike SR 141716A, NESS 0327 at higher doses does not act as a CB1 receptor inverse agonist and does not produce any physiological effects of its own.1,2

1 Ruiu, S., Pinna, G.A., Marchese, G., et al. Synthesis and characterization of NESS 0327: A novel putative antagonist of the CB1 cannabinoid receptor. J Pharmacol Exp Ther 306(1) 363-370 (2003).

2 Tambaro, S., Mongeau, R., Dessi, C., et al. Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors. Eur J Pharmacol 525 150-153 (2005).

Formal Name 8-​chloro-​1-​(2,​4-​dichlorophenyl)-​1,​4,​5,​6-​tetrahydro-​N-​1-​piperidinyl-​benzo[6,​7]cyclohepta[1,​2-​c]pyrazole-​3-​carboxamide
CAS Number 494844-07-4
Molecular Formula C24H23Cl3N4O
Formula Weight 489.8
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Clc1ccc2c(CCCc3c(nn(c23)​c2ccc(Cl)​cc2Cl)​C(=O)​NN2CCCCC2)​c1
Size Price Quantity Subtotal
1 mg $158.00 $0.00
5 mg $711.00 $0.00
10 mg $1,264.00 $0.00
25 mg $2,765.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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