Cayman Chemical | CAY10429 | Description • Abnormal Cannabidiol; Abn-CBD (CAS 22972-55-0)

10004259 CAY10429

Abnormal Cannabidiol; Abn-CBD (CAS 22972-55-0)

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Traditionally, the activity of cannabinoid (CB) agonists was thought to be transduced by a pair of G protein-coupled receptors, CB₁ and CB₂.¹ CAY10429 (abnormal cannabidiol) is a synthetic regioisomer of cannabidiol that fails to elicit either CB₁ or CB₂ responsiveness and is without psychotropic activity. CAY10429 induces endothelium-dependent vasodilation via a CB₁/CB₂/NO-independent mechanism.² At a dose of 20 µg/g in rats, CAY10429 showed hypotensive activity that could not be antagonized by cannabidiol or SR141716A. CAY10429 is therefore believed to activate a third type of CB receptor, provisionally called the non-CB₁/CB₂ endocannabinoid receptor. CAY10429 also acts via these receptors to regulate the migratory activity of murine BV-2 microglial cells, with an EC₅₀ of 600 nM.³

1 Felder, C.C., Joyce, K.E., Briley, E.M., et al. Comparison of the pharmacology and signal transduction of the human cannabinoid CB₁ and CB₂ receptors. Mol Pharmacol 48 443-450 (1995).

2 Járai, Z., Wagner, J.A., Varga, K., et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB₁ or CB₂ receptors. Proc Natl Acad Sci USA 96(24) 14136-14141 (1999).

3 Walter, L., Franklin, A., Witting, A., et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci 23(4) 1398-1405 (2003).

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Pricing updated 2010-03-13.
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