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Prostaglandin D Synthase (lipocalin-type; mouse) Polyclonal Antibody

Cayman Chemical Item Number 10004344

Lipocalin-PGDS; L-PGDS

Prostaglandin D Synthase (lipocalin-type; mouse) Polyclonal Antibody

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Description

Antigen: recombinant mouse L-PGD synthase · Host: rabbit · Application(s): WB and IHC · Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin type enzyme (β-trace) and the hematopoietic enzyme.1,2 Lipocalin-type PGDS (L-PGDS) is localized in the central nervous system, genital organs of various mammals and the human heart.1,3,4,5 Patients with chronic renal failure and hypertension exhibit elevated amounts of L-PGDS in serum and urine.6 The L-PGD synthase has been identified as β-trace, which is a major protein in the human cerebrospinal fluid.2,7

1 Eulitz, K., Yurawecz, M.P., Sehat, N., et al. Preparation, separation, and confirmation of the eight geometrical cis/trans conjugated linoleic acid isomers 8,10- through 11,13-18:2. Lipids 34 873-877 (1999).

2 Toh, H., Kubodera, H., Nakajima, N., et al. Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. Protein Eng 9 1067-1082 (1996).

3 Tokugawa, Y., Kunishige, I., Kuboto, Y., et al. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biol Reprod 58 600-607 (1998).

4 Melegos, D.N., Diamandis, E.P., Oda, H., et al. Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. Clin Chem 42 1984-1991 (1996).

5 Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur J Biochem 267 3315-3322 (2000).

6 Hirawa, N., Uehara, Y., Yamakado, M., et al. Lipocalin-type prostaglandin D synthase in essential hypertension. Hypertension 39 (part 2) 449-454 (2002 Dec 12).

7 Zahn, M., Mäder, A., Schmidt, B., et al. Purification and N-terminal sequence of β-trace, a protein abundant in human cerebrospinal fluid. Neurosci Lett 154 93-95 (1993).

Synonyms
  • Lipocalin-PGDS
  • L-PGDS
Formulation Protein-A purified rabbit IgG, lyophilized
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human L-PGDS +
Mouse L-PGDS +

Background Reading

Urade, Y., Watanabe, K., and Hayaishi, O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 12 257-273 (1995).

Hirawa, N., Uehara, Y., Yamakado, M., et al. Lipocalin-type prostaglandin D synthase in essential hypertension. Hypertension 39 (part 2) 449-454 (2002 Dec 12).

Zahn, M., Mäder, A., Schmidt, B., et al. Purification and N-terminal sequence of β-trace, a protein abundant in human cerebrospinal fluid. Neurosci Lett 154 93-95 (1993).

Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur J Biochem 267 3315-3322 (2000).

Toh, H., Kubodera, H., Nakajima, N., et al. Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins. Protein Eng 9 1067-1082 (1996).

Melegos, D.N., Diamandis, E.P., Oda, H., et al. Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids. Clin Chem 42 1984-1991 (1996).

Tokugawa, Y., Kunishige, I., Kuboto, Y., et al. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biol Reprod 58 600-607 (1998).

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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