Cayman Chemical | Prostaglandin D Synthase (hematopoietic-type; murine recombinant)

10004347 Prostaglandin D Synthase (hematopoietic-type; murine recombinant)

H-PGDS; Hematopoietic-PGDS

• See more EMSA (Electrophoretic Mobility Shift Assay); Enzyme Activity; Fluorescence Polarization; High Throughput Screening; Inhibitor Screening Assay; Molecular Biology; Enzymes; Proteins; Recombinant Proteins; Allergy/Asthma; Inflammation

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Source: Murine recombinant enzyme purified from E. coli overexpression system · M_r: 23.5 kDa · Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH₂ to produce PGD₂. PGD₂ induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (b-trace) and the hematopoietic enzyme.^1,2,3,4 Lipocalin-type PGDS is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as b-trace, which is a major protein in human cerebrospinal fluid.^3,4 Hematopoietic-PGDS is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes.¹ This enzyme, which requires glutathione for activity, belongs to the sigma-class of glutathione-S-transferases and is 23.5 kDa in size.^1,5,4

1 Kanaoka, Y., Fujimori, K., Kikuno, R., et al. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Eur J Biochem 267 3315-3322 (2000).

2 Jowsey, I.R., Thomson, A.M., Flanagan, J.U., et al. Mammalian class sigma glutathione s-transferases: Catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D₂ synthases. Biochem J 359 507-516 (2001).

3 Urade, Y., Watanabe, K., Hayaishi, O. Prostaglandin D, E, and F synthases. J Lipid Mediat Cell Signal 12 257-273 (1995).

4 Kanaoka, Y., Ago, H., Inagaki, E., et al. Cloning and crystal structure of hematopoietic prostaglandin D synthase. Cell 90 1085-1095 (1997).

5 Urade, Y., Fujimoto, N., Ujihara, M., et al. Biochemical and immunological characterization of rat spleen prostaglandin D synthetase. J Biol Chem 262(8) 3820-3825 (1987).

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Pricing updated 2010-03-11.
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