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16(S)-HETE

Cayman Chemical Item Number 10004384

(CAS 183509-23-1)

16(S)-HETE (CAS 183509-23-1)

See more	Eicosanoids (216) Cytochrome P450 (88) Endocrinology (335) Hypertension (90) Renal Disease (32)

Description

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(S)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 µM.¹

1 Carroll, M.A., Balazy, M., Margiotta, P., et al. Cytochrome P-450-dependent HETEs: Profile of biological activity and stimulation by vasoactive peptides. Am J Physiol 271 R863-R869 (1996).

Formal Name	16S-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
CAS Number	183509-23-1
Molecular Formula	C₂₀H₃₂O₃
Formula Weight	320.5
Formulation	A solution in ethanol
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCC(O)/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O

Background Reading

Reddy, Y.K., Reddy, L.M., Capdevila, J.H., et al. Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. Bioorg Med Chem Lett 13 3719-3720 (2003).

Yu, M., Alonso-Galicia, M., Sun, C., et al. 20-hydroxyeicosatetraenoic acid (20-HETE): Structural determinants for renal vasoconstriction. Bioorg Med Chem Lett 11 2803-2821 (2003).

Size	Price	Quantity	Subtotal
25 µg	$120.00		$0.00
50 µg	$228.00		$0.00
100 µg	$432.00		$0.00
500 µg	$1,920.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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