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Sulindac

Cayman Chemical Item Number 10004386

(CAS 38194-50-2)

Sulindac (CAS 38194-50-2)

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Description

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.1 Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of cyclooxygenase (COX-2) was discovered.2 Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.3

1 Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

2 Shen, T., and Winter, C.A. Chemical and biological studies on indomethacin, sulindac, and their analogs. Adv Drug Res 12 89-98 (1977).

3 Boolbol, S.K., Dannenberg, A.J., Chadburn, A., et al. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res 56 2556-2560 (1996).

Formal Name 5-​fluoro-​2-​methyl-​1Z-​[[4-​(methylsulfinyl)phenyl]methylene]-​1H-​indene-​3-​acetic acid
CAS Number 38194-50-2
Molecular Formula C20H17FO3S
Formula Weight 356.4
Formulation A crystalline solid
Purity >98%
λmax 226, 258, 286, 329 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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Fc1ccc2/C(=C\c3ccc(cc3)​S(=O)​C)​\C(=C(CC(=O)​O)​c2c1)​C

Background Reading

Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys Acta 1209 130-139 (1994).

Boolbol, S.K., Dannenberg, A.J., Chadburn, A., et al. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res 56 2556-2560 (1996).

Shen, T., and Winter, C.A. Chemical and biological studies on indomethacin, sulindac, and their analogs. Adv Drug Res 12 89-98 (1977).

Sulindac is available in the following screening library:

Size Price Quantity Subtotal
1 g $9.00 $0.00
5 g $41.00 $0.00
10 g $72.00 $0.00
50 g $315.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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