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Reversine

Cayman Chemical Item Number 10004412

(CAS 656820-32-5)

See more	Cancer (606) Stem Cell Research (23)

Description

Terminal differentiation of embryonic progenitor cells to form distinct, adult tissues is the hallmark of organogenesis in complex organisms. However, in mammals including humans, this process is not readily reversible. Reversine is a 2,6-disubstituted purine derivative that was identified using a screening system based on the loss of terminal differentiation markers in C2C12 myoblast cells.¹ Cultured myoblasts treated for four days with 5 µM reversine were dedifferentiated into confluent stem cell progenitors, that could then be induced by osteogenic or adipogenic medium to re-differentiate into bone or adipose precursors, respectively. Reversine is thus an important tool for the study of the control of cell fate.

1 Chen, S., Zhang, Q., Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc 126 410-411 (2004).

Formal Name	N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine
CAS Number	656820-32-5
Molecular Formula	C₂₁H₂₇N₇O
Formula Weight	393.5
Formulation	A crystalline solid
Purity	>98%
λ_max	283 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2[nH]cnc12

Background Reading

Chen, S., Zhang, Q., Wu, X., et al. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc 126 410-411 (2004).

Size	Price	Quantity	Subtotal
1 mg	$28.00		$0.00
5 mg	$126.00		$0.00
10 mg	$224.00		$0.00
25 mg	$490.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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