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TP Receptor (human) Polyclonal Antibody

Cayman Chemical Item Number 10004452

TXA2 Receptor; Thromboxane A2 Receptor

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Description

Antigen: human TP receptor C-terminal amino acids 323-343 (LSTRPRSLSLQPQLTQRSGLQ) · Host: rabbit · Application(s): WB and ICC · Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor.1 The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta.2,3,4,5 The apparent molecular weight for TP receptors has been reported from 37 kDa to 70 kDa, depending on different degrees of glycosylation.6,5,7 However Cayman’s antibody consistently detects the TP receptor at 55 and 64 kDa in platelet, kidney, and Cos-7 cell samples. Cayman Chemical’s TP receptor polyclonal antibody can be used for western blot and immunocytochemical analysis for both the TPA and TPB splice variants of the receptor on samples of human, murine, rat, and Cos-7 (African green monkey) origin.

1 Hirata, M., Hayashi, Y., Ushikubi, F., et al. Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature 349 617-620 (1991).

2 Namba, T., Sugimoto, Y., Hirata, M., et al. Mouse thromboxane A2 receptor: cDNA cloning, expression and Northern blot analysis. Biochem Biophys Res Commun 184 1197-1203 (1992).

3 Båtshake, B., Nilsson, C., and Sundelin, J. Structure and expression of the murine thromboxane A2 receptor gene. Biochem Biophys Res Commun 256 391-397 (1999).

4 Mais, D.E., True, T.A., and Martinelli, M.J. Characterization by photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor: Evidence for N-linked glycosylation. Eur J Pharmacol 227 267-274 (1992).

5 Takahashi, N., Takeuchi, K., Abe, T., et al. Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology 137 5170-5173 (1996).

6 Wang, G., Zhu, Y., Halushka, P.V., et al. Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA 95 4888-4893 (1998).

7 Habib, A., Fitzgerald, G.A., and Maclouf, J. Phosphorylation of the thromboxane receptor α, the predominant isoform expressed in human platelets. J Biol Chem 274 2645-2651 (1999).

Synonyms
  • TXA2 Receptor
  • Thromboxane A2 Receptor
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human TP receptor +
Mouse TP receptor +
Rat TP receptor +
Cos-7 (African green monkey) +
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Background Reading

Hirata, M., Hayashi, Y., Ushikubi, F., et al. Cloning and expression of cDNA for a human thromboxane A2 receptor. Nature 349 617-620 (1991).

Namba, T., Sugimoto, Y., Hirata, M., et al. Mouse thromboxane A2 receptor: cDNA cloning, expression and Northern blot analysis. Biochem Biophys Res Commun 184 1197-1203 (1992).

Mais, D.E., True, T.A., and Martinelli, M.J. Characterization by photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor: Evidence for N-linked glycosylation. Eur J Pharmacol 227 267-274 (1992).

Wang, G., Zhu, Y., Halushka, P.V., et al. Mechanism of platelet inhibition by nitric oxide: In vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA 95 4888-4893 (1998).

Cadroy, Y., and Harker, L.A. Platelets, thrombosis, and antithrombotic therapies. 3rd ed. 515-539 (1990).

Armstrong, R.A. Platelet Prostanoid Receptors. Pharmacotherapy 72 171-191 (1996).

Ellis, E.F., Oelz, O., Roberts, L.J., et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193 1135-1137 (1976).

Janssen, L.J., and Tazzeo, T. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. J Pharmacol Exp Ther 301(3) 1060-1066 (2002).

Dogné, J., de Leval, X., Benoit, P., et al. Therapeutic potential of thromboxane inhibitors in asthma. Expert Opin Investig Drugs 11(2) 1-8 (2003).

Habib, A., Fitzgerald, G.A., and Maclouf, J. Phosphorylation of the thromboxane receptor α, the predominant isoform expressed in human platelets. J Biol Chem 274 2645-2651 (1999).

Takahashi, N., Takeuchi, K., Abe, T., et al. Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology 137 5170-5173 (1996).

Båtshake, B., Nilsson, C., and Sundelin, J. Structure and expression of the murine thromboxane A2 receptor gene. Biochem Biophys Res Commun 256 391-397 (1999).

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Size Price Quantity Subtotal
500 µl $229.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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