15-Lipoxygenase-2 Blocking Peptide

Cayman Chemical Item Number 10004457

15-LO-2; 15-LOX-2; Arachidonate 15-Lipoxygenase Type II

Description

Peptide sequence: human 15-Lipoxygenase-2 (15-LO-2) amino acids 163-181 (CLDEKTVEDLELNIKYSTA) · To be used in conjunction with Cayman’s 15-LO-2 polyclonal antibody (Catalog No. 10004454) to block protein-antibody complex formation during immunochemical analysis of 15-LO-2.

Synonyms

15-LO-2
15-LOX-2
Arachidonate 15-Lipoxygenase Type II

Formulation

200 µg lyophilized peptide

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Background Reading

Kuhn, H., Barnett, J., Grunberger, D., et al. Overexpression, purification and characterization of human recombinant 15-lipoxygenase. Biochem Biophys Acta 1169(1) 80-89 (1993).

Kilty, I., Logan, A., and Vickers, P.J. Differential characteristics of human 15-lipoxygenase isozymes and novel splice variant of 15S-lipoxygenase. Eur J Biochem 266 83-93 (1999).

Jack, G.S., Brash, A.R., Olson, S.J., et al. Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: Correlation with grade and expression in high-grade prostatic intraepithelial neoplasia. Hum Pathol 31(9) 1146-1154 (2000).

Shappell, S.B., Boeglin, W.E., Olson, S.J., et al. 15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma. Am J Pathol 155 235-245 (1999).

Tang, S., Bhatia, B., Maldonado, C.J., et al. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. J Biol Chem 277(18) 16189-16201 (2002).

Brash, A.R., Chang, M.S., and Boeglin, W.E. Discovery of a second 15S-lipoxygenase in humans. Proc Natl Acad Sci USA 94 6148-6152 (1997).

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Size

Price

Quantity

Subtotal

200 µg

$107.00

$0.00

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