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11β-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody

Cayman Chemical Item Number 10004549

Corticosteroid 11β-Dehydrogenase Isozyme 2; 11β-HSD2

11β-Hydroxysteroid Dehydrogenase (Type 2) Polyclonal Antibody

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Description

Antigen: human 11β-Hydroxysteroid dehydrogenase (Type 2) (11β-HSD2) amino acids 25-40 (RSDLRLGRPLLAALAL) · Host: rabbit · Application(s): WB and ICC; other applications not tested · 11β-HSD2 plays a critical role in normal physiology in the corticosteroid regulation of sodium homeostasis and the pathophysiology of hypertension by converting active cortisol to inactive cortisone. Mutation in the gene encoding 11β-HSD2 results in cortisol induction of hypertension and hypokalemia, a syndrome of apparent mineralocorticoid excess.1 11β-HSD2 mRNA and protein are expressed in placenta and mineralocorticoid target tissues, particularly the kidney.2 In mouse, expression of this enzyme is tissue-specific and developmentally regulated, indicating the importance of the enzyme in controlling glucocorticoid-mediated maturation.3 Cayman’s 11β-HSD2 polyclonal antibody can be used for western blotting and immunochemical analysis of 11β-HSD2 from samples of human, rat, and mouse. The antibody detects a band at 44 kDa in tissues such as kidney and cell lines including Caco-2 cells and HT-29 cells.

1 Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 88(6) 2384-2392 (2003).

2 White, P.C., Mune, T., and Agarwal, A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18(1) 135-156 (1997).

3 Thompson, A., Han, V.K.M., and Yang, K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. J Steroid Biochem Mol Biol 88 367-375 (2004).

Synonyms
  • Corticosteroid 11β-Dehydrogenase Isozyme 2
  • 11β-HSD2
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human 11β-HSD2 +
Mouse 11β-HSD2 +
Rat 11β-HSD2 +

Background Reading

Quinkler, M., and Stewart, P.M. Hypertension and the cortisol-cortisone shuttle. J Clin Endocrinol Metab 88(6) 2384-2392 (2003).

Thompson, A., Han, V.K.M., and Yang, K. Differential expression of 11β-hydroxysteroid dehydrogenase types 1 and 2 mRNA and glucocorticoid receptor protein during mouse embryonic development. J Steroid Biochem Mol Biol 88 367-375 (2004).

White, P.C., Mune, T., and Agarwal, A.K. 11β-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18(1) 135-156 (1997).
Size Price Quantity Subtotal
500 µl $229.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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