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CD37 Monoclonal Antibody (Clone IPO-24)

Cayman Chemical Item Number 10004718

See more	Flow Cytometry (113) Immunocytochemistry (144) Immunohistochemistry (213) Antibodies (677) Apoptosis (191) Cancer (666) Immunology (187)

Description

Clone designation: IPO-24 · Host: mouse · Application(s): (+) flow cytometry, immunocytochemistry, and immunohistochemistry (frozen and paraffin sections); (−) western blot · CD37 is a type III transmembrane glycoprotein (M_r = 40-52 kDa). The leukocyte-specific protein CD37 is a member of the tetraspanin superfamily, originally described as a cell surface glycoprotein expressed on mature human B cells, but not on pro-B cells or plasma cells.^1,2 T cells and monocytes express CD37 at low levels. In humans, CD37 expression is restricted to B and T lymphocytes, monocytes, macrophages, neutrophils, dendritic cells, and certain leukocyte-derived malignant cells. CD37 is not expressed by NK cells, platelets, or erythrocytes.³ CD37 monoclonal antibody is recommended for immunophenotyping of B cell neoplasia (B cell chronic lymphocytic leukemia, hairy cell leukemia, and B cell non-Hodgkin’s lymphomas). Human, rat, and murine CD37 sequences have been identified.^4,5

1 Maecker, H.T., Todd, S.C., and Levy, S. The tetraspanin superfamily: Molecular facilitators. FASEB J 11 428-442 (1997).

2 Knobeloch, K., Wright, M.D., Ochsenbein, A.F., et al. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol 20(15) 5363-5369 (2000).

3 van Spriel, A.B., Puls, K.L., Sofi, M., et al. A regulatory role for CD37 in T cell proliferation. J Immunol 172 2953-2961 (2004).

4 Tomlinson, M.G., and Wright, M.D. Characterisation of mouse CD37: cDNA and genomic cloning. Mol Immunol 33(10) 867-872 (1996).

5 Classon, B.J., Williams, A.F., Willis, A.C., et al. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. J Exp Med 169 1497-1502 (1989).

Formulation

100 µg affinity-purified IgG2b in 500 µl PBS, pH 7.2, containing 0.02% sodium azide

Stability

1 year

Storage

4°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

human CD37

Background Reading

Maecker, H.T., Todd, S.C., and Levy, S. The tetraspanin superfamily: Molecular facilitators. FASEB J 11 428-442 (1997).

van Spriel, A.B., Puls, K.L., Sofi, M., et al. A regulatory role for CD37 in T cell proliferation. J Immunol 172 2953-2961 (2004).

Knobeloch, K., Wright, M.D., Ochsenbein, A.F., et al. Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol 20(15) 5363-5369 (2000).

Tomlinson, M.G., and Wright, M.D. Characterisation of mouse CD37: cDNA and genomic cloning. Mol Immunol 33(10) 867-872 (1996).

Classon, B.J., Williams, A.F., Willis, A.C., et al. The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. J Exp Med 169 1497-1502 (1989).

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Size	Price	Quantity	Subtotal
1 ea	$229.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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