Clone designation: 203.6 · Host: mouse · Application(s): ICC, IHC (frozen tissue sections), and flow cytometry; (−) western blot; immunohistochemistry (formalin-fixed paraffin-embedded sections) not tested · CD27 is a type II homodimeric transmembrane glycoprotein (M_r = 55 kDa) and a member of the nerve growth factor/tumor necrosis receptor superfamily.^1,2 The antigen was identified on medullar thymocytes, mature T lymphocytes (CD45RA+CD45RO- T-cell subpopulation), memory B cells, plasma, and NK cells. This antibody is well suited for immunohistochemical detection of CD27 in B cell non-Hodgkin’s lymphoma samples.

1 Prasad, K.V.S., Ao, Z., Yoon, Y., et al. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci USA 94 6346-6351 (1997).

2 Camerini, D., Walz, G., Loenen, W.A.M., et al. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J Immunol 147 3165-3169 (1991).

Prasad, K.V.S., Ao, Z., Yoon, Y., et al. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci USA 94 6346-6351 (1997).

Camerini, D., Walz, G., Loenen, W.A.M., et al. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J Immunol 147 3165-3169 (1991).