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Antigen:
mouse LPA3 N-terminal amino acids 1-12
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Host:
rabbit
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Application(s):
WB and ICC
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Lysophosphatidic Acid Receptor 3 (LPA3, also known as edg-7) is one of three lysophosphatidic acid (LPA) receptors (LPA1, LPA2, LPA3) that are members of large family of G-protein coupled receptors (GPCRs) that also include those for sphingosine-1-phosphate (S1P1-5).1 The LPA receptors mediate many cellular responses including cytoskeletal rearrangements, cell proliferation, and inhibition of gap junction communication.2,3 Murine and human LPA3 have 353 amino acids with an estimated molecular weight of 40 kDa.4,5 The mRNA level of LPA3 is high in testes, kidney, and lung but low in intestine, heart, thymus, and stomach.5 Cayman Chemical’s LPA3 polyclonal antibody can be used for western blot and immunocytochemical analysis for LPA3 on samples of human, murine, and rat origin. Cayman’s LPA3 polyclonal antibody detects a protein at around 40 kDa in human Hep-G2 cells, murine macrophages, and in murine and rat liver.
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1
Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).
2
Fukushima, N., Chun, J. The LPA receptors. Prostaglandins and Other Lipid Mediators 64 21-32 (2001).
3
Contos, J.J.A., Ishii, I., Chun, J. Lysophosphatidic Acid Receptors. Mol Pharmacol 58 1188-1196 (2000).
4
Bandoh, K., Aoki, J., Hosono, H., et al. Molecular cloning and characteristics of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 274(39) 27776-27785 (1999).
5
Contos, J.J.A., Chun, J. The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267 243-253 (2001).
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