Antigen: mouse LPA₃ N-terminal amino acids 1-12 · Host: rabbit · Application(s): WB and ICC · Lysophosphatidic Acid Receptor 3 (LPA₃, also known as edg-7) is one of three lysophosphatidic acid (LPA) receptors (LPA₁, LPA₂, LPA₃) that are members of large family of G-protein coupled receptors (GPCRs) that also include those for sphingosine-1-phosphate (S1P_1-5).¹ The LPA receptors mediate many cellular responses including cytoskeletal rearrangements, cell proliferation, and inhibition of gap junction communication.^2,3 Mouse and human LPA₃ have 353 amino acids with an estimated molecular weight of 40 kDa.^4,5 The mRNA level of LPA₃ is high in testes, kidney, and lung but low in intestine, heart, thymus, and stomach.⁵ Cayman Chemical’s LPA₃ polyclonal antibody can be used for western blot and immunocytochemical analysis for LPA₃ on samples of human, mouse, and rat origin. Cayman’s LPA₃ polyclonal antibody detects a protein at around 40 kDa in human Hep-G₂ cells, mouse macrophages, and in mouse and rat liver.

1 Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).

2 Fukushima, N., and Chun, J. The LPA receptors. Prostaglandins Other Lipid Mediat 64 21-32 (2001).

3 Contos, J.J.A., Ishii, I., and Chun, J. Lysophosphatidic Acid Receptors. Mol Pharmacol 58 1188-1196 (2000).

4 Bandoh, K., Aoki, J., Hosono, H., et al. Molecular cloning and characteristics of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 274(39) 27776-27785 (1999).

5 Contos, J.J.A., and Chun, J. The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267 243-253 (2001).

Bandoh, K., Aoki, J., Hosono, H., et al. Molecular cloning and characteristics of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 274(39) 27776-27785 (1999).

Fukushima, N., and Chun, J. The LPA receptors. Prostaglandins Other Lipid Mediat 64 21-32 (2001).

Contos, J.J.A., Ishii, I., and Chun, J. Lysophosphatidic Acid Receptors. Mol Pharmacol 58 1188-1196 (2000).

Contos, J.J.A., and Chun, J. The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Gene 267 243-253 (2001).

Chun, J., Goetzl, E.J., Hla, T., et al. International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev 54 265-269 (2002).

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