Cayman Chemical | O-1918 | Description (CAS 536697-79-7)

10004914 O-1918

(CAS 536697-79-7)

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• See more Receptor Biochemistry; Cannabinoids; Hypertension; Neuroscience; Signal Transduction; Vascular Disease

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Abnormal cannabidiol is a synthetic regioisomer of cannabidiol that fails to elicit either central cannabinoid (CB₁) or peripheral cannabinoid (CB₂) responsiveness and is without psychotropic activity. It induces endothelium-dependent vasodilation via a CB₁/CB₂/nitric oxide-independent mechanism.¹ O-1918 is a cannabidiol analog that acts as a selective antagonist of abnormal cannabidiol at the non-CB₁/CB₂ endothelial receptor. It does not bind to CB₁ or CB₂ receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of abnormal cannabidiol in vitro and in whole animals.² It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells.²

1 Járai, Z., Wagner, J.A., Varga, K., et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB₁ or CB₂ receptors. Proc Natl Acad Sci USA 96(24) 14136-14141 (1999).

2 Offertáler, L., Mo, F., Bátkai, S., et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 63(3) 699-705 (2003).

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Pricing updated 2010-03-13.
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