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FABP4 Polyclonal Antibody

Cayman Chemical Item Number 10004944

Fatty Acid Binding Protein 4; aP2; A-FABP; ALBP; Adipocyte-FABP

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Description

Antigen: human FABP4 amino acids 103-118 · Host: rabbit · Application(s): WB and ICC; other applications not tested · FABP4 is primarily expressed in adipocytes but is also expressed in activated macrophages, indicating that the protein plays a critical role in foam cell formation and thus atherosclerosis.1,2 FABP4 was first purified from mouse 3T3-L1 adipocytes and then from human adipocytes and was named ALBP.3,4 The expression of FABP4 is developmentally regulated by fatty acids, PPARγ agonists, and insulin.5,6 In mice, deficiency of FABP4 prevents the development of hyperinsulinemia and insulin resistance in genetic and diet-induced obesity.7,8 Cayman’s FABP4 polyclonal antibody can be used for western blot and immunocytochemical analysis on samples of human, rat, and murine origin.

1 Perrella, M.A., Pellacani, A., Layne, M.D., et al. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15 1774-1776 (2001).

2 Boord, J.B., Maeda, K., Makowski, L., et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22 1686-1691 (2002).

3 Matarese, V., and Bernlohr, D.A. Purification of murine adipocyte lipid-binding protein. Characterization as a fatty acid- and retinoic acid-binding protein. J Biol Chem 263(28) 14544-14551 (1988).

4 Baxa, C.A., Sha, R.S., Buelt, M.K., et al. Human adipocyte lipid-binding protein: Purification of the protein and cloning of its complementary DNA. Biochemistry 28 8683-8690 (1989).

5 Distel, R.J., Robinson, G.S., and Spiegelman, B.M. Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. J Biol Chem 267(9) 5937-5941 (1992).

6 Melki, S.A., and Abumrad, N.A. Expression of the adipocyte fatty acid-binding protein in streptozotocin-diabetes: Effects of insulin deficiency and supplemenatation. J Lipid Res 34 1527-1534 (1993).

7 Hotamisligil, G.S., Johnson, R.S., Distel, R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 1377-1379 (1996).

8 Uysal, K.T., Scheja, L., Wiesbrock, S.M., et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9) 3388-3396 (2000).

Synonyms
  • Fatty Acid Binding Protein 4
  • aP2
  • A-FABP
  • ALBP
  • Adipocyte-FABP
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human FABP4 +
Mouse FABP4 +
Rat FABP4 +

Background Reading

Perrella, M.A., Pellacani, A., Layne, M.D., et al. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15 1774-1776 (2001).

Baxa, C.A., Sha, R.S., Buelt, M.K., et al. Human adipocyte lipid-binding protein: Purification of the protein and cloning of its complementary DNA. Biochemistry 28 8683-8690 (1989).

Distel, R.J., Robinson, G.S., and Spiegelman, B.M. Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. J Biol Chem 267(9) 5937-5941 (1992).

Melki, S.A., and Abumrad, N.A. Expression of the adipocyte fatty acid-binding protein in streptozotocin-diabetes: Effects of insulin deficiency and supplemenatation. J Lipid Res 34 1527-1534 (1993).

Uysal, K.T., Scheja, L., Wiesbrock, S.M., et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9) 3388-3396 (2000).

Hotamisligil, G.S., Johnson, R.S., Distel, R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 1377-1379 (1996).

Matarese, V., and Bernlohr, D.A. Purification of murine adipocyte lipid-binding protein. Characterization as a fatty acid- and retinoic acid-binding protein. J Biol Chem 263(28) 14544-14551 (1988).

Boord, J.B., Maeda, K., Makowski, L., et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22 1686-1691 (2002).

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Size Price Quantity Subtotal
500 µl $229.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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