10004944  FABP4 Polyclonal Antibody

Fatty Acid Binding Protein 4; aP2; A-FABP; ALBP

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• See more Immunocytochemistry; Molecular Biology; Western Blot; Antibodies; Fatty Acids; PPAR; Atherosclerosis; Endocrinology; Metabolism; Obesity

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Antigen: human FABP4 amino acids 103-118 · Host: rabbit · Application(s): WB and ICC; other applications not tested · FABP4 is primarily expressed in adipocytes but is also expressed in activated macrophages, indicating that the protein plays a critical role in foam cell formation and thus atherosclerosis.1,2 FABP4 was first purified from murine 3T3-L1 adipocytes and then from human adipocytes and was named ALBP.3,4 The expression of FABP4 is developmentally regulated by fatty acids, PPARγ agonists, and insulin.5,6 In mice, deficiency of FABP4 prevents the development of hyperinsulinemia and insulin resistance in genetic and diet-induced obesity.7,8 Cayman’s FABP4 polyclonal antibody can be used for western blot and immunocytochemical analysis on samples of human, rat, and murine origin.
1  Perrella, M.A., Pellacani, A., Layne, M.D., et al. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15 1774-1776 (2001).
2  Boord, J.B., Maeda, K., Makowski, L., et al. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22 1686-1691 (2002).
3  Matarese, V., Bernlohr, D.A. Purification of murine adipocyte lipid-binding protein. Characterization as a fatty acid- and retinoic acid-binding protein. J Biol Chem 263(28) 14544-14551 (1988).
4  Baxa, C.A., Sha, R.S., Buelt, M.K., et al. Human adipocyte lipid-binding protein: Purification of the protein and cloning of its complementary DNA. Biochemistry 28 8683-8690 (1989).
5  Distel, R.J., Robinson, G.S., Spiegelman, B.M. Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms. J Biol Chem 267(9) 5937-5941 (1992).
6  Melki, S.A., Abumrad, N.A. Expression of the adipocyte fatty acid-binding protein in streptozotocin-diabetes: Effects of insulin deficiency and supplemenatation. J Lipid Res 34 1527-1534 (1993).
7  Hotamisligil, G.S., Johnson, R.S., Distel, R.J., et al. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274 1377-1379 (1996).
8  Uysal, K.T., Scheja, L., Wiesbrock, S.M., et al. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology 141(9) 3388-3396 (2000).


Purchase 10004944 FABP4 Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-16.
Prices are subject to change without notice.

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