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Leptomycin B

Cayman Chemical Item Number 10004976

NSC 364372; Mantuamycin; LMB; Elactocin (CAS 87081-35-4)

Leptomycin B (CAS 87081-35-4)

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Description

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins.1 Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins (export factors).2 By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation.3 Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..

1 Kudo, N., Wolff, B., Sekimoto, T., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res 242 540-547 (1998).

2 Nishi, K., Yoshida, M., Fujiwara, D., et al. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem 269(9) 6320-6324 (1994).

3 Smart, P., Lane, E.B., Lane, D.P., et al. Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene 18 7378-7386 (1999).

Synonyms
  • NSC 364372
  • Mantuamycin
  • LMB
  • Elactocin
Formal Name 19-​[(2S,​3S)-​3,​6-​dihydro-​3-​methyl-​6-​oxo-​2H-​pyran-​2-​yl]-​17-​ethyl-​6-​hydroxy-​3,​5S,​7S,​9R,​11,​15R,​hexamethyl-​8-​oxo-​2E,​10E,​12E,​16Z,​18E-​nonadecapentaenoic acid
CAS Number 87081-35-4
Molecular Formula C33H48O6
Formula Weight 540.7
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC/C(=C/C(C)​C/C=C/C(=C\[C@@H]​(C)​C(=O)​[C@@H]​(C)​[C@H]​(O)​[C@@H]​(C)​C\C(=C\C(=O)​O)​\C)​\C)​/C=C\[C@@H]​1OC(=O)​C=C[C@@H]​1C

Background Reading

Kudo, N., Wolff, B., Sekimoto, T., et al. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res 242 540-547 (1998).

Nishi, K., Yoshida, M., Fujiwara, D., et al. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem 269(9) 6320-6324 (1994).

Smart, P., Lane, E.B., Lane, D.P., et al. Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B. Oncogene 18 7378-7386 (1999).
Size Price Quantity Subtotal
5 µg $217.00 $0.00
10 µg $412.00 $0.00
25 µg $977.00 $0.00
50 µg $1,736.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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