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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Caylin-1

Cayman Chemical Item Number 10004985

Caylin-1

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Description

Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity.1 Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT-116 cells with an IC50 value of approximately 7 µM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 µM, caylin-1 promotes the growth of HCT-116 cells approximately 20% compared to untreated cells.2 The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.

1 Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).

2 missing reference text

Formal Name 4-​[4,​5-​bis(3,​4-​chlorophenyl)-​2-​(2-​isopropoxy-​4-​methoxy-​phenyl)-​4,​5-​dihydro-​imidazole-​1-​carboxyl]-​piperazin-​2-​one
Molecular Formula C30H28Cl4N4O4
Formula Weight 650.4
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(c(OC(C)​C)​c1)​C1=N[C@@H]​(c2ccc(Cl)​c(Cl)​c2)​[C@@H]​(c2ccc(Cl)​c(Cl)​c2)​N1C(=O)​N1CCNC(=O)​C1

Background Reading

Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).
Size Price Quantity Subtotal
1 mg $50.00 $0.00
5 mg $225.00 $0.00
10 mg $400.00 $0.00
50 mg $1,750.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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