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CAY10433

Cayman Chemical Item Number 10005019

BML-210; N-phenyl-N'-(2-Aminophenyl)hexamethylenediamide (CAS 537034-17-6)

CAY10433 (CAS 537034-17-6)

See more	Histone Deacetylase (14) Apoptosis (191) Cancer (666) Gene Regulation (203)

Description

Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation.¹ CAY10433 is a small molecule inhibitor of HDAC with an IC₅₀ value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate² (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits - Catalog Nos. 10011563 and 10011564). CAY10433 also inhibits the deacetylation of the transcription factor FOXO3 by mammalian SIRT1 in cells oxidatively stressed by hydrogen peroxide.³

1 Yoshida, M., Kijima, M., Akita, M., et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 (1990).

2 Johnson, J. BK617. (2007).

3 Brunet, A., Sweeney, L.B., Sturgill, J.F., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-2015 (2004).

Synonyms	BML-210 N-phenyl-N'-(2-Aminophenyl)hexamethylenediamide
Formal Name	N-(2-aminophenyl)-N'-phenyl-octanediamide
CAS Number	537034-17-6
Molecular Formula	C₂₀H₂₅N₃O₂
Formula Weight	339.4
Formulation	A crystalline solid
Purity	>98%
λ_max	241 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(CCCCCCC(=O)Nc1ccccc1N)Nc1ccccc1

Background Reading

Yoshida, M., Kijima, M., Akita, M., et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 (1990).

Johnson, J. BK617. (2007).

Brunet, A., Sweeney, L.B., Sturgill, J.F., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-2015 (2004).

CAY10433 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$46.00		$0.00
5 mg	$207.00		$0.00
10 mg	$368.00		$0.00
25 mg	$805.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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