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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

5(S),6(R)-7-trihydroxymethyl Heptanoate

Cayman Chemical Item Number 10005032

BML-111

5(S),6(R)-7-trihydroxymethyl Heptanoate

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Description

Lipoxins are trihydroxytetraene metabolites derived from arachidonic acid through an interaction between lipoxygenases with C-5 and C-15 specificities. Lipoxin A4 (LXA4) inhibits the chemotactic responsiveness of polymorphonuclear (PMN) neutrophils to leukotriene B4 and to the peptide formyl-methionyl-leucyl-phenylalanine (fMLP).1 5(S),6(R)-7-trihydroxymethyl heptanoate is a C-7 truncated analog of LXA4 that is equiactive as LXA4 in the inhibition of LTB4-induced PMN chemotaxis with an IC50 of 5nM.1

1 Lee, T.H., Lympany, P., Crea, A.E.G., et al. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships. Biochem Biophys Res Commun 180(3) 1416-1421 (1991).

Synonyms
  • BML-111
Formal Name 5S,​6R-​trihydroxy-​7-​heptanoic acid,​ methyl ester
Molecular Formula C8H16O5
Formula Weight 192.2
Formulation A solution in methanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC[C@@H]​(O)​[C@@H]​(O)​CCCC(OC)​=O

Background Reading

Lee, T.H., Lympany, P., Crea, A.E.G., et al. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships. Biochem Biophys Res Commun 180(3) 1416-1421 (1991).

5(S),6(R)-7-trihydroxymethyl Heptanoate is available in the following screening library:

Size Price Quantity Subtotal
1 mg $41.00 $0.00
5 mg $185.00 $0.00
10 mg $328.00 $0.00
100 mg $2,460.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

5(S),6(R)-Lipoxin A4
5(S),6(R)-Lipoxin A4 methyl ester

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