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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Eicosapentaenoic Acid-d5

Cayman Chemical Item Number 10005056

EPA-d5; Timnodonic Acid-d5 (CAS 145191-14-6)

Eicosapentaenoic Acid-d5 (CAS 145191-14-6)

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Description

Eicosapentaenoic Acid-d5 (EPA-d5) contains five deuterium atoms at the 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of EPA by GC- or LC-mass spectrometry. EPA is an ω-3 fatty acid abundantly available in marine organisms. It is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid.1 EPA has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases.2,3

1 Wada, M., DeLong, C.J., Hong, Y.H., et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282(31) 22254-22266 (2007).

2 Yerram, N.R., Moore, S.A., and Spector, A.A. Eicosapentaenoic acid metabolism in brain microvessel endothelium: Effect on prostaglandin formation. J Lipid Res 30 1747-1757 (1989).

3 Takeuchi, H., Inoue, J., Yoshida, M., et al. Dietary effects of n-3 eicosapentaenoic acid on essential fatty acid-deficiency symptoms of rats. Agric Biol Chem 53 3225-3232 (1989).

Synonyms
  • EPA-d5
  • Timnodonic Acid-d5
Formal Name 5Z,​8Z,​11Z,​14Z,​17Z-​eicosapentaenoic-​19,​19,​20,​20,​20-​d5 acid
CAS Number 145191-14-6
Molecular Formula C20H25D5O2
Formula Weight 307.5
Formulation A solution in ethanol
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​O

Background Reading

Wada, M., DeLong, C.J., Hong, Y.H., et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282(31) 22254-22266 (2007).

Takeuchi, H., Inoue, J., Yoshida, M., et al. Dietary effects of n-3 eicosapentaenoic acid on essential fatty acid-deficiency symptoms of rats. Agric Biol Chem 53 3225-3232 (1989).

Yerram, N.R., Moore, S.A., and Spector, A.A. Eicosapentaenoic acid metabolism in brain microvessel endothelium: Effect on prostaglandin formation. J Lipid Res 30 1747-1757 (1989).
Size Price Quantity Subtotal
50 µg $52.00 $0.00
100 µg $99.00 $0.00
500 µg $416.00 $0.00
1 mg $728.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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