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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Docosahexaenoic Acid-d5

Cayman Chemical Item Number 10005057

DHA-d5; Cervonic Acid-d5

Docosahexaenoic Acid-d5

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Description

Docosahexaenoic Acid-d5 (DHA-d5) contains five deuterium atoms at the 21, 21, 22, 22 and 22 positions. It is intended for use as an internal standard for the quantification of DHA by GC- or LC-mass spectrometry. DHA is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. DHA constitutes as much as 40% of the total polyunsaturated fatty acid pool in retinal and neuronal membranes.1 Supplementation of dietary DHA using fish oil inhibits the progression of atherosclerosis and delays photoreceptor degeneration in retinitis pigmentosa.2 Neonatal DHA deprivation causes developmental defects and can lead to hypertension in rats.3

1 Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317 (1986).

2 Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res 60 279-289 (1995).

3 Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7(3) 258-259 (2001).

Synonyms
  • DHA-d5
  • Cervonic Acid-d5
Formal Name 4Z,​7Z,​10Z,​13Z,​16Z,​19Z-​docosahexaenoic-​21,​21,​22,​22,​22-​d5 acid
Molecular Formula C22H27D5O2
Formula Weight 333.5
Formulation A solution in ethanol
Purity ≥99% deuterated product
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCCCC(=O)​O

Background Reading

Salem, N., Kim, H., and Yergey, J.A. Docosahexaenoic acid: Membrane function and metabolism. 263-317 (1986).

Weisinger, H.S., Armitage, J.A., Sinclair, A.J., et al. Perinatal ω-3 fatty acid deficiency affects blood pressure later in life. Nat Med 7(3) 258-259 (2001).

Hoffman, D.R., Uauy, R., and Birch, D.G. Metabolism of ω-3 fatty acids in patients with autosomal dominant retinitis pigmentosa. Exp Eye Res 60 279-289 (1995).
Size Price Quantity Subtotal
50 µg $49.00 $0.00
100 µg $93.00 $0.00
500 µg $392.00 $0.00
1 mg $686.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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