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10005072 CAY10455
SKM 4-45-1
(CAS 290374-09-3)
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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
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The cellular trafficking of arachidonoyl ethanolamide (anandamide; AEA) by neurons is dominated by transport and/or hydrolysis by fatty acyl amide hydrolase (FAAH) within the neurons.1 CAY10455 is a labeled analog of AEA that is non-fluorescent when outside the cell. Upon transport into the cell interior, it is cleaved by esterases to give a bright fluorescence at 530 nm. CAY10455 uptake into C6 glioma cells is inhibited by AEA and its analogs, and conversely CAY10455 inhibits the uptake of tritiated AEA, indicating that they compete for the AEA transporter.2
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1
Deutsch, D.G., Glaser, S.T., Howell, J.M., et al. The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. J Biol Chem 276(10) 6967-6973 (2001).
2
Muthian, S., Nithipatikom, K., Campbell, W.B., et al. Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. J Pharmacol Exp Ther 293 289-295 (2000).
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Pricing updated 2010-03-19.
Prices are subject to change without notice.
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Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.
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