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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

AMC Arachidonoyl Amide

Cayman Chemical Item Number 10005098

7-amino-4-methyl Coumarin-Arachidonamide; AMC-AA

AMC Arachidonoyl Amide

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Description

AMC arachidonoyl amide (AMC-AA) is one of several fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity.1 FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide (AEA).2 Exposure of AMC-AA to FAAH activity results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm. This allows the fast and convenient measurement of FAAH activity using a simple cuvette or microplate fluorometer.

1 Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

2 Patricelli, M.P., and Cravatt, B.F. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. Biochemistry 40 6107-6115 (2001).

Synonyms
  • 7-amino-4-methyl Coumarin-Arachidonamide
  • AMC-AA
Formal Name 7-​amino-​4-​methyl-​2H-​1-​benzopyran-​2-​one-​5Z,​8Z,​11Z,​14Z-​eicosatetraenamide
Molecular Formula C30H39NO3
Formula Weight 461.6
Formulation A crystalline solid
Purity >98%
λmax 229, 328 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)​Nc1ccc2c(C)​cc(=O)​oc2c1

Background Reading

Patricelli, M.P., and Cravatt, B.F. Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase. Biochemistry 40 6107-6115 (2001).

Cravatt, B.F., Giang, D.K., Mayfield, S.P., et al. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384 83-87 (1996).

AMC Arachidonoyl Amide is available in the following screening library:

Size Price Quantity Subtotal
5 mg $65.00 $0.00
10 mg $124.00 $0.00
25 mg $293.00 $0.00
50 mg $520.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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