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10005099 17(R)-HDoHE
17(R)-hydroxy Docosahexaenoic Acid
(CAS 155976-53-7)
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Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals.1 17(R)-HDoHE is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2. 17(R)-HDoHE serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFα-induced IL-1β expression in human glioma cells.1
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1
Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals. J Exp Med 196(8) 1025-1037 (2002).
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Pricing updated 2010-03-16.
Prices are subject to change without notice.
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