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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Genistein

Cayman Chemical Item Number 10005167

(CAS 446-72-0)

Genistein (CAS 446-72-0)

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Description

Genistein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, and other legumes. The estimated human normal dietary intake of genistein, primarily as glycosides, is 0 to 0.5 mg/kg. Genistein is present in much greater amounts in nutritional supplements. Genistein is carcinogenic in female neonatal mice, inducing endocrine-dependent uterine tumors in a fashion similar to diethylstilbestrol (DES).1 Genistein is a tyrosine-specific inhibitor of protein kinase activity, blocking the tyrosine-phosphorylation of histone H2B.2 In adult animals, dietary genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors.3

1 Newbold, R.R., Banks, E.P., Bullock, B., et al. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61 4325-4328 (2001).

2 Akiyama, T., Ishida, J., Nakagawa, S., et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262(1) 5592-5595 (1987).

3 Lamartiniere, C.A., Cotroneo, M.S., Fritz, W.A., et al. Genistein chemoprevention: Timing and mechanisms of action in murine mammary and prostate. J Nutr 132 552S-558S (2002).

Formal Name 5,​7-​dihydroxy-​3-​(4-​hydroxyphenyl)-​4H-​1-​benzopyran-​4-​one
CAS Number 446-72-0
Molecular Formula C15H10O5
Formula Weight 270.2
Formulation A crystalline solid
Purity ≥98%
λmax 261 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1ccc(cc1)​c1coc2cc(O)​cc(O)​c2c1=O

Background Reading

Newbold, R.R., Banks, E.P., Bullock, B., et al. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61 4325-4328 (2001).

Lamartiniere, C.A., Cotroneo, M.S., Fritz, W.A., et al. Genistein chemoprevention: Timing and mechanisms of action in murine mammary and prostate. J Nutr 132 552S-558S (2002).

Akiyama, T., Ishida, J., Nakagawa, S., et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262(1) 5592-5595 (1987).

Genistein is available in the following screening library:

Size Price Quantity Subtotal
100 mg $37.00 $0.00
250 mg $88.00 $0.00
500 mg $167.00 $0.00
1 g $296.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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