Cayman Chemical | Genistein | Description (CAS 446-72-0)

10005167 Genistein

(CAS 446-72-0)

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• See more Antioxidants; Flavonoids; Cancer; Endocrinology; Nutrition/Diet; Oxidative Injury

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Genistein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, and other legumes. The estimated human normal dietary intake of genistein, primarily as glycosides, is 0 to 0.5 mg/kg. Genistein is present in much greater amounts in nutritional supplements. Genistein is carcinogenic in female neonatal mice, inducing endocrine-dependent uterine tumors in a fashion similar to diethylstilbestrol (DES).¹ Genistein is a tyrosine-specific inhibitor of protein kinase activity, blocking the tyrosine-phosphorylation of histone H2B.² In adult animals, dietary genistein has chemopreventive effects on breast, prostate, and other endocrine-dependent tumors.³

1 Newbold, R.R., Banks, E.P., Bullock, B., et al. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61 4325-4328 (2001).

2 Akiyama, T., Ishida, J., Nakagawa, S., et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262(1) 5592-5595 (1987).

3 Lamartiniere, C.A., Cotroneo, M.S., Fritz, W.A., et al. Genistein chemoprevention: Timing and mechanisms of action in murine mammary and prostate. J Nutr 132 552S-558S (2002).

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Pricing updated 2009-07-04.
Prices are subject to change without notice.