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Quercetin

Cayman Chemical Item Number 10005169

(CAS 117-39-5)

Quercetin (CAS 117-39-5)

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Description

Quercetin is a flavonoid compound found in the bark and rinds of many plants and fruits.1 The estimated human normal dietary intake of quercetin, primarily as glycosides, is 0.1-0.2 mg/kg.2 Quercetin is present in much greater amounts in nutritional supplements. Quercetin is carcinogenic in male rats, inducing renal adenomas when fed at 2,000 mg/kg.3 Quercetin has been reported to inhibit phosphodiesterases of both cGMP and cAMP.4,5

1 Gschwendt, M., Horn, F., Kittstein, W., et al. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.. Biochem Biophys Res Commun 117(2) 444-447 (1983).

2 Young, J.F., Nielsen, S.E., Haraldsdottir, J., et al. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status.. Am J Clin Nutr 69(1) 87-94 (1999).

3 . Toxicology and carcinogenesis studies of quercetin in F344 rats. National Toxicology Program 1-171 (1992 Sep 1).

4 Ruckstuhl, M., Beretz, A., and Anton, R. Flavonoids are selective cyclic GMP phosphodiesterase inhibitors.. Biochem Pharmacol 28(4) 535-538 (1979).

5 Lang, D.R., and Racker, E. Effect of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles.. Biochim Biophys Acta 333(2) 180-186 (1974).

Formal Name 2-​(3,​4-​dihydroxyphenyl)-​3,​5,​7-​trihydroxy-​4H-​1-​benzopyran-​4-​one
CAS Number 117-39-5
Molecular Formula C15H10O7
Formula Weight 302.2
Formulation A crystalline solid
Purity >95%
λmax 256, 368 nm
Stability 2 years
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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Oc1cc(O)​c2c(c1)​oc(c1ccc(O)​c(O)​c1)​c(O)​c2=O

Background Reading

Young, J.F., Nielsen, S.E., Haraldsdottir, J., et al. Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status.. Am J Clin Nutr 69(1) 87-94 (1999).

Ruckstuhl, M., Beretz, A., and Anton, R. Flavonoids are selective cyclic GMP phosphodiesterase inhibitors.. Biochem Pharmacol 28(4) 535-538 (1979).

Gschwendt, M., Horn, F., Kittstein, W., et al. Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.. Biochem Biophys Res Commun 117(2) 444-447 (1983).

. Toxicology and carcinogenesis studies of quercetin in F344 rats. National Toxicology Program 1-171 (1992 Sep 1).

Lang, D.R., and Racker, E. Effect of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particles.. Biochim Biophys Acta 333(2) 180-186 (1974).

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Quercetin is available in the following screening library:

Size Price Quantity Subtotal
5 g $12.00 $0.00
10 g $23.00 $0.00
50 g $96.00 $0.00
100 g $168.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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