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CAY10441 Exclusive

Cayman Chemical Item Number 10005186

RO1138452 (CAS 221529-58-4)

CAY10441 (CAS 221529-58-4)

See more	Receptor Biochemistry (59) Prostaglandins (513) Atherosclerosis (323) Hypertension (90) Neuroscience (654) Vascular Disease (103)

Description

Recently, a series of relatively simple compounds were found to be high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor.¹ CAY10441 is one of the more potent of these. CAY10441 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a K_i of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays.¹

1 Clark, R.D., Jahangir, A., Severance, D., et al. Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg Med Chem Lett 14 1053-1056 (2004).

Synonyms	RO1138452
Formal Name	4,5-dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imadazol-2-amine
CAS Number	221529-58-4
Molecular Formula	C₁₉H₂₃N₃O
Formula Weight	309.4
Formulation	A crystalline solid
Purity	>98%
λ_max	232 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CC(C)Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1

Background Reading

Clark, R.D., Jahangir, A., Severance, D., et al. Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg Med Chem Lett 14 1053-1056 (2004).

CAY10441 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$51.00		$0.00
5 mg	$230.00		$0.00
10 mg	$408.00		$0.00
25 mg	$893.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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