Cayman Chemical | FABP1 (rat recombinant) | Description • Liver-Fatty Acid Binding Protein; Fatty Acid Binding Protein 1; Liver-FABP; L-FABP

10005200 FABP1 (rat recombinant)

Liver-Fatty Acid Binding Protein; Fatty Acid Binding Protein 1; Liver-FABP; L-FABP

• See more Protein Binding; Fatty Acid Binding Proteins; Fatty Acids; Proteins; Recombinant Proteins; Atherosclerosis; Endocrinology; Fatty Acid Transport

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli · M_r: 18.3 kDa · Protein concentration: 0.5 mg/ml · Fatty acid binding protein 1 (FABP1) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.¹ FABP1 is composed of ten antiparallel β strands that form a barrel with a bigger binding pocket than the other FABPs allowing it to accommodate two fatty acids. Expression of FABP1 is decreased in hepatoblastoma and hepatocellular carcinoma making the protein a potential tumor marker. Moreover, studies have suggested FABP1 as a potential biomarker for both liver and kidney injury.¹ Cayman’s FABP1 has been functionally characterized by a fluorescence displacement assay using the fluorescent fatty acid analogue 11-(dansyl amino)undecanoic acid (DAUDA). Both arachidonic acid and oleic acid effectively displace DAUDA from the FABP binding pocket in a concentration-dependent manner.

1 Zimmerman, A.W., Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).

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Pricing updated 2010-03-19.
Prices are subject to change without notice.