FABP1 (rat recombinant)
Cayman Chemical Item Number 10005200
Liver-Fatty Acid Binding Protein; Fatty Acid Binding Protein 1; Liver-FABP; L-FABP
Description
Source:
recombinant N-terminal hexahistidine-tagged protein expressed in E. coli
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Mr:
18.3 kDa
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Protein concentration:
0.5 mg/ml
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Fatty acid binding protein 1 (FABP1) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids.1 FABP1 is composed of ten antiparallel β strands that form a barrel with a bigger binding pocket than the other FABPs allowing it to accommodate two fatty acids. Expression of FABP1 is decreased in hepatoblastoma and hepatocellular carcinoma making the protein a potential tumor marker. Moreover, studies have suggested FABP1 as a potential biomarker for both liver and kidney injury.1 Cayman’s FABP1 has been functionally characterized by a fluorescence displacement assay using the fluorescent fatty acid analogue 11-(dansyl amino)undecanoic acid (DAUDA). Both arachidonic acid and oleic acid effectively displace DAUDA from the FABP binding pocket in a concentration-dependent manner.
1
Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).
| Synonyms |
- Liver-Fatty Acid Binding Protein
- Fatty Acid Binding Protein 1
- Liver-FABP
- L-FABP
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| Formulation |
A solution in 50 mM sodium phosphate, pH 7.2, containing 20% glycerol and 150 mM sodium chloride |
| Purity |
>95% |
| Stability |
1 year |
| Storage |
-80°C |
| Shipping |
Dry ice
in continental US; may vary elsewhere
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Background Reading
Zimmerman, A.W., and Veerkamp, J.H. New insights into the structure and function of fatty acid-binding proteins. Cell Mol Life Sci 59 1096-1116 (2002).
Massolini, G., and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. J Chromatogr B 797 255-268 (2003).
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Pricing updated 2012-02-11.
Prices are subject to change without notice.
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Warning This product is not for human or veterinary use.
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.
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