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AFMK

Cayman Chemical Item Number 10005254

(CAS 52450-38-1)

AFMK (CAS 52450-38-1)

See more	Antioxidants (62) Endocrinology (335) Neuroscience (654) Oxidative Injury (258)

Description

Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK is a melatonin metabolite first identified in rat brain.¹ AFMK has antioxidant and free radical scavenging activities in several experimental models.² AFMK may also be measured in plasma as an index of melatonin synthesis and metabolism.³

1 Hirata, F., Hayaishi, O., Tokuyama, T., et al. In vitro and in vivo formation of two new metabolites of melatonin. J Biol Chem 249(4) 1311-1313 (1974).

2 Tan, D., Manchester, L.C., Burkhardt, S., et al. N1-acetyl-N2-forml-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 15 2294-2296 (2001).

3 Harthé, C., Claudy, D., Déchaud, H., et al. Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): A melatonin oxidative metabolite. Life Sci 73 1587-1597 (2003).

Formal Name	N-[3-[2-(formylamino)-5-methoxyphenyl]-3-oxypropyl]-acetamide
CAS Number	52450-38-1
Molecular Formula	C₁₃H₁₆N₂O₄
Formula Weight	264.3
Formulation	A crystalline solid
Purity	>98%
λ_max	236, 266, 352 nm
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=CNc1ccc(OC)cc1C(=O)CCNC(=O)C

Background Reading

Harthé, C., Claudy, D., Déchaud, H., et al. Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): A melatonin oxidative metabolite. Life Sci 73 1587-1597 (2003).

Tan, D., Manchester, L.C., Burkhardt, S., et al. N1-acetyl-N2-forml-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 15 2294-2296 (2001).

Hirata, F., Hayaishi, O., Tokuyama, T., et al. In vitro and in vivo formation of two new metabolites of melatonin. J Biol Chem 249(4) 1311-1313 (1974).

Size	Price	Quantity	Subtotal
1 mg	$18.00		$0.00
5 mg	$72.00		$0.00
10 mg	$108.00		$0.00
50 mg	$360.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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