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p53 Product Pack

Cayman Chemical Item Number 10005291

See more	Transcription Factors (24) Apoptosis (191) Cancer (666)

Description

The Cayman p53 Product Pack contains PRIMA-1, a p53 re-activator that restores the apoptotic activity of mutant p53 via conformational modulation.¹ Included in the p53-PAK is our phospho p53 (Ser³⁹²) antibody, as well as (±)-nutlin-3, a p53 activator working via inhibition of p53/Mdm2 binding.² Also included is caylin-2, a nutlin analog with growth enhancing properties at low concentrations that are opposite those of (±)-nutlin-3.³

1 Bykov, V.J.N., Issaeva, N., Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 8(3) 282-288 (2002).

2 Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).

3 missing reference text

Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere

Background Reading

Bykov, V.J.N., Issaeva, N., Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat Med 8(3) 282-288 (2002).

Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).

Size	Price	Quantity	Subtotal
1 ea	$513.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Caylin-2

(±)-Nutlin-3

p53DINP1 Polyclonal Antibody New

p53 (Phospho-Ser³⁹²) Polyclonal Antibody

PRIMA-1

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Downloads

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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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