Cayman Chemical | p53-PAK

10005291 p53-PAK

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• See more Transcription Factors; Apoptosis; Cancer

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

The Cayman p53-PAK contains PRIMA-1, a p53 re-activator that restores the apoptotic activity of mutant p53 via conformational modulation.¹ Included in the p53-PAK is our phospho p53 (Ser³⁹²) antibody, as well as (±)-nutlin-3, a p53 activator working via inhibition of p53/Mdm2 binding.² Also included is caylin-2, a nutlin analog with growth enhancing properties at low concentrations that are opposite those of (±)-nutlin-3.³

1 Bykov, V.J.N., Issaeva, N., Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nature Med 8(3) 282-288 (2002).

2 Vassilev, L.T., Vu, B.T., Graves, B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844-848 (2004).

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Purchase 10005291 p53-PAK

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-17.
Prices are subject to change without notice.

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