Atherosclerosis Product Pack
Cayman Chemical Item Number 10005292
Description
The Atherosclerosis Product Pack contains our human ACAT-1 polyclonal antibody and blocking peptide. Targeting human amino acids 6-23 of the acyl-Coenzyme A: cholesterol acyl transferase-1, these reagents can be used for western blot analysis and immunohistochemistry. Also included are several oxidized bioactive lipid species, including cholesteryl linoleate hydroperoxides,1,2 POV-PC,3 and PGPC.4
1
Brooks, C.J.W., Harland, W.A., Steel, G., et al. Lipids of human atheroma: Isolation of hydroxyoctadecadienoic acids from advanced aortal lesions. Biochim Biophys Acta 202 563-566 (1970).
2
Lenz, M.L., Hughes, H., Mitchell, J.R., et al. Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. J Lipid Res 31 1043-1050 (1990).
3
Podrez, E.A., Batyreva, B., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem 277(41) 38503-38516 (2002).
4
Leitinger, N., Tyner, T.R., Oslund, L., et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci USA 96(21) 12010-12015 (1999).
| Stability |
6 months |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
Background Reading
Brooks, C.J.W., Harland, W.A., Steel, G., et al. Lipids of human atheroma: Isolation of hydroxyoctadecadienoic acids from advanced aortal lesions. Biochim Biophys Acta 202 563-566 (1970).
Leitinger, N., Tyner, T.R., Oslund, L., et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci USA 96(21) 12010-12015 (1999).
Okamoto, H., Yonemori, F., Wakitani, K., et al. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 406 203-206 (2000).
Podrez, E.A., Batyreva, B., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. J Biol Chem 277(41) 38503-38516 (2002).
Lenz, M.L., Hughes, H., Mitchell, J.R., et al. Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. J Lipid Res 31 1043-1050 (1990).
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Pricing updated 2012-02-12.
Prices are subject to change without notice.
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Warning This product is not for human or veterinary use.
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