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Fenofibrate

Cayman Chemical Item Number 10005368

(CAS 49562-28-9)

Fenofibrate (CAS 49562-28-9)

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Description

PPARα is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.3 Fenofibrate is PPARα agonist and a member of a class of hypolipidemic drugs that includes clofibrate and benzafibrate, which have been used clinically to treat dyslipidemia and cardiovascular disease. In a transactivation assay, fenofibrate exhibits EC50 values of 18 and 30 µM for murine and human PPARα, respectively.4 It also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM.

1 Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

2 Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

3 Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

4 Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

Formal Name 2-​[4-​(4-​chlorobenzoyl)phenoxy]-​2-​methyl-​propanoic acid,​ 1-​methylethyl ester
CAS Number 49562-28-9
Molecular Formula C20H21ClO4
Formula Weight 360.8
Formulation A crystalline solid
Purity ≥98%
λmax 287 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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ClC1=CC=C(C(C2=CC=C(OC(C)​(C(OC(C)​C)​=O)​C)​C=C2)​=O)​C=C1

Background Reading

Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

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Fenofibrate is available in the following screening library:

Size Price Quantity Subtotal
1 g $9.00 $0.00
5 g $41.00 $0.00
10 g $72.00 $0.00
50 g $315.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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