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Fenofibrate

Cayman Chemical Item Number 10005368

(CAS 49562-28-9)

Fenofibrate (CAS 49562-28-9)

See more	Nuclear Receptors (86) PPAR (59) Atherosclerosis (323) Cardiology (79) Endocrinology (335) Metabolism (139) Obesity (162) Vascular Disease (103)

Description

PPARα is a ligand-activated transcription factor involved in the regulation of lipid homeostasis.^1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport.³ Fenofibrate is PPARα agonist and a member of a class of hypolipidemic drugs that includes clofibrate and benzafibrate, which have been used clinically to treat dyslipidemia and cardiovascular disease. In a transactivation assay, fenofibrate exhibits EC₅₀ values of 18 and 30 µM for murine and human PPARα, respectively.⁴ It also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM.

1 Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

2 Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

3 Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

4 Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

Formal Name	2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester
CAS Number	49562-28-9
Molecular Formula	C₂₀H₂₁ClO₄
Formula Weight	360.8
Formulation	A crystalline solid
Purity	≥98%
λ_max	287 nm
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ClC1=CC=C(C(C2=CC=C(OC(C)(C(OC(C)C)=O)C)C=C2)=O)C=C1

Background Reading

Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79 81-94 (1997).

Lemberger, T., Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12 335-363 (1996).

Mandard, S., Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci 61 393-416 (2004).

Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J Med Chem 43(4) 528-550 (2000).

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Fenofibrate is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 g	$9.00		$0.00
5 g	$41.00		$0.00
10 g	$72.00		$0.00
50 g	$315.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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