10005518  IP Receptor (human) Polyclonal Antibody

Prostaglandin I2 Receptor; Prostacyclin Receptor; PGI2 Receptor

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• See more Western Blot; Antibodies; Atherosclerosis; Hypertension; Inflammation; Neuroscience

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Antigen: human IP receptor N-terminal amino acids 1-16 conjugated to KLH (MADSCRNLTYVRGSVG) · Host: rabbit · Application(s): WB; other applications not tested · Prostaglandin I2 (PGI2) is a potent vasorelaxant and inhibitor of human platelet aggregation.1 The PGI2 receptor (IP receptor) also participates in signal transduction of the pain response, cardioprotection, and inflammation.2,3,4,5,6 Cloning of the murine and human IP receptors revealed a significant amino-terminal truncation of the human IP receptor compared to the murine receptor.7,8 Cayman Chemical’s IP receptor antibody detects a 67 kDa band on immunoblot. The predicted migration of the deglycosylated protein is 40 kDa and bands at either 67 or 40 kDa may be detected depending on the degree of post-translational modification of the sample.9
1  Aristoff, P.A., Johnson, P.D., Harrison, A.W. Synthesis of 9-substituted carbacyclin analogues. J Org Chem 48 5341-5348 (1983).
2  Southall, M.D., Vasko, M.R. Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. J Biol Chem 276(19) 16083-16091 (2001).
3  Murata, T., Ushikubi, F., Matsuoka, T., et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388 678-682 (1997).
4  Cheng, Y., Austin, S.C., Rocca, B., et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296 539-541 (2002).
5  Cui, Y., Kataoka, Y., Satoh, T., et al. Protective effect of prostaglandin I2 analogs on ischemic delayed neuronal damage in gerbils. Biochem Biophys Res Commun 265 301-304 (1999).
6  McLaughlin, V.V., Genthner, D.E., Panella, M.M., et al. Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension. N Engl J Med 338 273-277 (1998).
7  Nakagawa, O., Tanaka, I., Usui, T., et al. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Circulation 90 1643-1647 (1994).
8  Namba, T., Oida, H., Sugimoto, Y., et al. cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla. J Biol Chem 269 9986-9992 (1994).
9  Smyth, E.M., Nestor, P.V., Fitzgerald, G.A. Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. J Biol Chem 271(52) 33698-33704 (1996).


Purchase 10005518 IP Receptor (human) Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-16.
Prices are subject to change without notice.

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