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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

N-Arachidonoyl Taurine Exclusive

Cayman Chemical Item Number 10005537

N-Arachidonoyl Taurine

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Description

Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl-L-serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectrometry lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, was discovered.2 This novel class or compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-arachidonoyl taurine, a prominent N-acyl taurine, activates both TRPV1 and TRPV4 with EC50 values of 28 and 21 µM, respectively.3

1 Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J Biol Chem 276(46) 42639-42644 (2001).

2 Cravatt, B.F., and Maxey, K.M. . (2004).

3 Saghatelian, A., McKinney, M.K., Bandell, M., et al. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry 45(30) 9007-9015 (2006).

Formal Name 2-​[(1-​oxo-​5Z,​8Z,​11Z,​14Z-​eicosatetraenyl)amino]-​ethane sulfonic acid
Molecular Formula C22H37NO4S
Formula Weight 411.6
Formulation A solution in methanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N(CCS(=O)​(O)​=O)​[H]​)​=O

Background Reading

Saghatelian, A., McKinney, M.K., Bandell, M., et al. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry 45(30) 9007-9015 (2006).

Huang, S.M., Bisogno, T., Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J Biol Chem 276(46) 42639-42644 (2001).

Cravatt, B.F., and Maxey, K.M. . (2004).

N-Arachidonoyl Taurine is available in the following screening library:

Size Price Quantity Subtotal
500 µg $34.00 $0.00
1 mg $65.00 $0.00
5 mg $272.00 $0.00
10 mg $476.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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