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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Y-27632 (hydrochloride)

Cayman Chemical Item Number 10005583

(CAS 129830-38-2)

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Description

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of Rho-associated protein kinases including p160ROCK (Ki = 140 nM) and ROCK-II (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM.1,2 One-hour treatment with 10 nM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.3

1 Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 95-105 (2000).

2 Uehata, M., Ishizaki, T., Satoh, H., et al. Calcium sensitization of smooth muscle mediated by a Rho-assocciated protein kinase in hypertension. Nature 389 990-994 (1997).

3 Watanabe, K., Ueno, M., Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech 25(6) 681-686 (2007).

Formal Name 4-​[(1R)-​1-​aminoethyl]-​N-​4-​pyridinyl-​trans-​cyclohexanecarboxamide,​ dihydrochloride
CAS Number 129830-38-2
Molecular Formula C14H21N3O · 2HCl
Formula Weight 320.3
Formulation A crystalline solid
Purity >98%
λmax 204, 270 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C([C@H]​1CCC([C@H]​(N)​C)​CC1)​NC2=CC=NC=C2

Background Reading

Uehata, M., Ishizaki, T., Satoh, H., et al. Calcium sensitization of smooth muscle mediated by a Rho-assocciated protein kinase in hypertension. Nature 389 990-994 (1997).

Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 95-105 (2000).

Y-27632 (hydrochloride) is available in the following screening library:

Size Price Quantity Subtotal
500 µg $31.00 $0.00
1 mg $59.00 $0.00
5 mg $248.00 $0.00
10 mg $434.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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