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CAY10448

Cayman Chemical Item Number 10005633

CAY10448

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Description

Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper.1 Capsaicin signals are transduced by a heat-activated ion channel, the vanilloid receptor 1 (VR1), or transient receptor potential vanilloid 1 (TRPV1).2 CAY10448 is an iodinated nonivamide, a potent capsaicin receptor antagonist with an IC50 of approximately 10 nM.3

1 Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. J Org Chem 53(5) 1064-1071 (1988).

2 Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 816-824 (1997).

3 Daddario, N., Minassi, A., Appendino, G., et al. The taming of capsaicin. Synthesis and vanilloid antagonistic activity of isosteric and regioisomeric halononiv amides and their products of halogen-carbon exchange. 14th Annual Symposium on the Cannabinoids 137 (2004).

Formal Name N-​[(4-​hydroxy-​2-​iodo-​3-​methoxyphenyl)methyl]-​8-​methyl-​nonanamide
Molecular Formula C18H28INO3
Formula Weight 433.3
Formulation A crystalline solid
Purity ≥98%
λmax 210, 236, 287 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1cc(CNC(=O)​CCCCCCC(C)​C)​c(I)​cc1O

Background Reading

Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. J Org Chem 53(5) 1064-1071 (1988).

Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 816-824 (1997).

Daddario, N., Minassi, A., Appendino, G., et al. The taming of capsaicin. Synthesis and vanilloid antagonistic activity of isosteric and regioisomeric halononiv amides and their products of halogen-carbon exchange. 14th Annual Symposium on the Cannabinoids 137 (2004).

CAY10448 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $16.00 $0.00
5 mg $72.00 $0.00
10 mg $128.00 $0.00
50 mg $560.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Capsaicin
Capsaicin (technical grade)
Capsazepine
Dihydrocapsaicin
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